The influence of CYP3A, PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients
I Lunde, S Bremer, K Midtvedt, B Mohebi… - European journal of …, 2014 - Springer
Abstract Purpose Tacrolimus (Tac) and cyclosporine (CsA) are mainly metabolized by
CYP3A4 and CYP3A5. Several studies have demonstrated an association between the …
CYP3A4 and CYP3A5. Several studies have demonstrated an association between the …
Genotype-guided tacrolimus dosing in African-American kidney transplant recipients
K Sanghavi, RC Brundage, MB Miller… - The …, 2017 - nature.com
Tacrolimus is dependent on CYP3A5 enzyme for metabolism. Expression of the CYP3A5
enzyme is controlled by several alleles including CYP3A5* 1, CYP3A5* 3, CYP3A5* 6 and …
enzyme is controlled by several alleles including CYP3A5* 1, CYP3A5* 3, CYP3A5* 6 and …
Which genetic determinants should be considered for tacrolimus dose optimization in kidney transplantation? A combined analysis of genes affecting the CYP3A locus
H Bruckmueller, AN Werk, L Renders… - Therapeutic drug …, 2015 - journals.lww.com
Background: Tacrolimus is established as immunosuppressant after kidney transplantation.
Polymorphism of the cytochrome P450 3A5 (CYP3A5) gene contributes significantly to …
Polymorphism of the cytochrome P450 3A5 (CYP3A5) gene contributes significantly to …
Evaluation of pharmacogenetics of drug-metabolizing enzymes and drug efflux transporter in renal transplants receiving immunosuppressants
K Sridharan, S Shah, A Jassim, M Hammad… - Journal of Personalized …, 2022 - mdpi.com
Cytochrome P450 (CYP) enzymes, such as CYP3A4, and CYP3A5, P450 oxidoreductase
(POR), peroxisome proliferator activated receptor alpha (PPAR-alpha), and drug transporter …
(POR), peroxisome proliferator activated receptor alpha (PPAR-alpha), and drug transporter …
Influence of combined CYP3A4 and CYP3A5 single-nucleotide polymorphisms on tacrolimus exposure in kidney transplant recipients: a study according to the post …
K Aouam, A Kolsi, E Kerkeni, N Ben Fredj… - …, 2015 - Future Medicine
Aim: The present study investigated in Tunisian renal transplant patients, genetic
polymorphisms of CYP3A4-392A> G and CYP3A5 6986A> G and their influence on …
polymorphisms of CYP3A4-392A> G and CYP3A5 6986A> G and their influence on …
Therapeutic concentration achievement and allograft survival comparing usage of conventional tacrolimus doses and CYP3A5 genotype‐guided doses in renal …
S Anutrakulchai, C Pongskul… - British Journal of …, 2019 - Wiley Online Library
Aims Although cytochromeP450 (CYP) 3A5 gene polymorphism affects personalized
tacrolimus doses, there is no consensus as to whether CYP3A5 genotypes should be …
tacrolimus doses, there is no consensus as to whether CYP3A5 genotypes should be …
Effect of genetic polymorphism of CYP3A5 and CYP2C19 and concomitant use of voriconazole on blood tacrolimus concentration in patients receiving hematopoietic …
T Iwamoto, F Monma, A Fujieda… - Therapeutic Drug …, 2015 - journals.lww.com
Background: Blood tacrolimus (TAC) concentration delivered via intravenous administration
is known to be influenced by genetic polymorphism of CYP3A5 and interaction with triazole …
is known to be influenced by genetic polymorphism of CYP3A5 and interaction with triazole …
The impact of donor and recipient genetic variation on outcomes after solid organ transplantation: a scoping review and future perspectives
Y Li, LM Nieuwenhuis, BJ Keating, EAM Festen… - …, 2022 - journals.lww.com
At the outset of solid organ transplantation, genetic variation between donors and recipients
was recognized as a major player in mechanisms such as allograft tolerance and rejection …
was recognized as a major player in mechanisms such as allograft tolerance and rejection …
Genetic polymorphisms and kidney transplant outcomes
S Chand, AJ McKnight, R Borrows - Current Opinion in …, 2014 - journals.lww.com
These studies set the scene for further investigation, aiming to understand pathways of
disease and biomarkers of risk, and are leading to a greater understanding of the biology of …
disease and biomarkers of risk, and are leading to a greater understanding of the biology of …
Machine learning‐based method for tacrolimus dose predictions in Chinese kidney transplant perioperative patients
Q Fu, Y Jing, G Liu Mr, X Jiang Mr, H Liu… - Journal of Clinical …, 2022 - Wiley Online Library
Abstract What is Known and Objectives Tacrolimus (TAC), a first‐line immunosuppressant in
solid‐organ transplant, has a narrow therapeutic window and large inter‐individual …
solid‐organ transplant, has a narrow therapeutic window and large inter‐individual …