Effects of three serotonin reuptake inhibitors on sign-tracking in male Sprague-Dawley rats

JM Holden - Physiology & Behavior, 2023 - Elsevier
Sign-tracking is a behavior with relevance to cue-triggered relapse addiction, a Pavlovian
conditioned approach behavior directed at the conditioned stimulus. The study examined …

Dextromethorphan reduces sign-tracking but not goal-tracking in male Sprague-Dawley rats

JM Holden, A Salem - Neurobiology of Learning and Memory, 2022 - Elsevier
Sign-tracking is a well-known phenomenon in appetitive Pavlovian conditioning in which
subjects approach the site of a conditioned stimulus (CS) associated with an appetitive …

Effects of bupropion on sign-and goal-tracking in male Sprague Dawley rats

JM Holden - Behavioural Brain Research, 2023 - Elsevier
Relapse into addiction is often triggered by cues that have a Pavlovian association with
drugs and drug-taking. Sign-tracking involves approach of and interaction with Pavlovian …

[HTML][HTML] Sign-tracking and goal-tracking in humans: Utilising eye-tracking in clinical and non-clinical populations

LM Dinu, AL Georgescu, SN Singh, NC Byrom… - Behavioural brain …, 2024 - Elsevier
Abstract Background In Pavlovian conditioning, learned behaviour varies according to the
perceived value of environmental cues. For goal-trackers (GT), the cue merely predicts a …

Acute MK-801 increases measures of both sign-tracking and goal-tracking in male Sprague-Dawley rats

JM Holden, A Barbaro, K Azure, M Arth - Pharmacology Biochemistry and …, 2024 - Elsevier
Sign-tracking is a Pavlovian conditioned approach behavior thought to be important in
understanding cue-driven relapse to drug use, and strategies for reducing sign-tracking may …

Memantine decreases measures of sign-tracking and increases measures of goal-tracking in male Sprague Dawley rats

JM Holden - Learning and Motivation, 2022 - Elsevier
Memantine is a drug which has antagonistic effects at N-methyl-D-aspartate and 5-
hydroxytryptamine 3 receptors. Its properties may make it especially effective at reducing …