The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …

Increased osteoclast (OC) differentiation and activity is the critical event that results in bone
loss and joint destruction in common pathological bone conditions, such as osteoporosis …

NF-κB is a critical link between inflammation and cancer, but whether long non-coding RNAs
(lncRNAs) regulate its activation remains unknown. Here, we identify an NF-KappaB …

Abstract The NF-κB (Nuclear Factor kappa B) transcription factor plays crucial roles in the
regulation of numerous biological processes including development of the immune system …

There is increasing evidence showing that inflammation is an important pathogenic mediator
of the development of obesity-induced insulin resistance. It is now generally accepted that …

Cathepsin B (CTSB) is a powerful lysosomal protease. This review evaluated CTSB gene
knockout (KO) outcomes for amelioration of brain dysfunctions in neurologic diseases and …

Cells engaging in inflammation undergo drastic changes of their transcriptomes. In order to
tailor these alterations in gene expression to the requirements of the inflammatory process …

Diabetic nephropathy (DN) as the primary cause of end-stage kidney disease is a common
complication of diabetes. Recent researches have shown the activation of nuclear factor …

Globally, breast cancer is the most common cancer type and is one of the most significant
causes of deaths in women. To date, multiple clinical interventions have been applied …

The NF-κB family of transcription factors plays a central role in the inducible expression of
inflammatory genes during the immune response, and the proper regulation of these genes …