During the evolution of Gram-negative bacteria, their outermost and major membrane
components, lipopolysaccharides (LPS), the constituents of the so-called endotoxin …

We recently described the capsule null locus (cnl) of constitutively unencapsulated
Neisseria meningitidis clonal lineages. cnl meningococci were recovered from healthy …

Two-component regulatory systems are involved in processes important for bacterial
pathogenesis. Inactivation of the misR/misS system in Neisseria meningitidis results in the …

Almost all invasive Neisseria meningitidis isolates express capsular polysaccharide. Ab is
required for complement-dependent killing of meningococci. Although alternative pathway …

We show that in a standardized in vitro flow system unencapsulated variants of genetically
diverse lineages of Neisseria meningitidis formed biofilms, that could be maintained for …

Novel therapeutics against multidrug-resistant Neisseria gonorrhoeae are urgently needed.
Gonococcal lipooligosaccharide often expresses lacto-N-neotetraose (LNnT), which …

Lipooligosaccharide (LOS) of Neisseria meningitidis is the major inflammatory mediator that
contributes to meningococcal pathogenesis. Variable attachments to the HepII residue of the …

Ab-initiated, complement-dependent killing contributes to host defenses against invasive
meningococcal disease. Sera from nonimmunized individuals vary widely in their …

We previously described a gene, lpt3, required for the addition of phosphoethanolamine
(PEtn) at the 3 position on the β-chain heptose (HepII) of the inner-core Neisseria …

Complement is a key arm of the innate immune defenses against the pathogenic neisseriae.
We previously identified lipooligosaccharide on Neisseria meningitidis as an acceptor for …