Predominant phosphorylation patterns in Neisseria meningitidis lipid A determined by top-down MS/MS

CM John, NJ Phillips, GA Jarvis - Journal of Lipid Research, 2020 - ASBMB
Among the virulence factors in Neisseria infections, a major inducer of inflammatory
cytokines is the lipooligosaccharide (LOS). The activation of NF-κB via extracellular binding …

The role of complement in gonococcal infection of cervical epithelia

JL Edwards - Vaccine, 2008 - Elsevier
Neisseria gonorrhoeae is an exclusive human pathogen that causes the sexually
transmitted disease, gonorrhea. The gonococcus has developed an exquisite repertoire of …

Bacterial complement escape

I Jongerius, S Ram, S Rooijakkers - Pathogen-Derived Immunomodulatory …, 2009 - Springer
Complement activation is a crucial step in our innate immune defense against invading
bacteria. Complement proteins can quickly recognize invading bacteria and subsequenly …

Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure

H Cheng, Z Yang, MM Estabrook, CM John… - Journal of Biological …, 2011 - ASBMB
Antibodies that initiate complement-mediated killing of Neisseria meningitidis as they enter
the bloodstream from the oropharynx protect against disseminated disease. Human IgGs …

The oligosaccharide of gonococcal lipooligosaccharide contains several epitopes that are recognized by human antibodies

R Yamasaki, U Yabe, C Kataoka, U Takeda… - Infection and …, 2010 - Am Soc Microbiol
Recently, we isolated human IgG from normal human sera (NHS) using lipooligosaccharide
(LOS) from gonococcal strain JW31R as an affinity ligand. We provided evidence that the …

Role of complement in defense against meningococcal infection

S Ram, U Vogel - Handbook of Meningococcal Disease …, 2006 - Wiley Online Library
C1r and C1s). Activated C1s in the complex first cleaves C4, which results in the separation
of 77 amino acids (C4a) from the N-terminal end of the C4 achain and the subsequent …

Структурный анализ липополисахаридов грамотрицательных бактерий обзор

ДС Кабанов, ИР Прохоренко - Биохимия, 2010 - elibrary.ru
Представлены данные по составу и структуре липида А, кора и О-полисахарида
изученных липополисахаридов грамотрицательных бактерий. Обсуждается …

Cloning, expression, purification and crystallization of an endotoxin-biosynthesis enzyme from Neisseria meningitidis

A Anandan, S Piek, CM Kahler… - … Section F: Structural …, 2012 - journals.iucr.org
The enzyme phosphoethanolamine transferase A is involved in the addition of
phosphoethanolamine moieties to lipid A in Neisseria meningitidis. The enzyme is …

Sequence-Based Predictions of Lipooligosaccharide Diversity in the Neisseriaceae and Their Implication in Pathogenicity

DC Stein, CJ Miller, SV Bhoopalan, DD Sommer - PLoS One, 2011 - journals.plos.org
Endotoxin [Lipopolysaccharide (LPS)/Lipooligosaccharide (LOS)] is an important virulence
determinant in gram negative bacteria. While the genetic basis of endotoxin production and …

[PDF][PDF] Молекулярно-генетические механизмы образования и функциональная значимость липополисахарида Yersinia pestis

СВ Дентовская - 2012 - researchgate.net
5 ПЕРЕЧЕНЬ СОКРАЩЕНИЙ, УСЛОВНЫХ ОБОЗНАЧЕНИЙ, СИМВОЛОВ, ЕДИНИЦ И
ТЕРМИНОВ (согласно M. Demerec et al.[140] и R. Novik et al.[360]) 12: 0-лауроильная …