Background: Cardiomyopathies are a heterogeneous group of pathologies characterized by
structural and functional alterations of the heart. Aims: The purpose of this narrative review is …

Our insight into the diverse and complex nature of dilated cardiomyopathy (DCM) genetic
architecture continues to evolve rapidly. The foundations of DCM genetics rest on marked …

Heart disease is the leading cause of death worldwide. Cardiomyopathy is a disease
characterized by the heart muscle damage, resulting heart in a structurally and functionally …

Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level
structural information from striated muscle fibers under hydrated physiological conditions …

It has been nearly 15 years since the discovery of human-induced pluripotent stem cells
(iPSCs). During this time, differentiation methods to targeted cells have dramatically …

Sudden death is one of the most common causes of death in humans in Western countries.
Approximately 85% of these cases are of cardiac origin. In dogs and cats, sudden cardiac …

Alternative splicing, a driver of posttranscriptional variance, differs from canonical splicing by
arranging the introns and exons of an immature pre-mRNA transcript in a multitude of …

Arrhythmogenic Cardiomyopathy (ACM), a Mendelian disorder that can affect both left and
right ventricles, is most often associated with pathogenic desmosomal variants that can lead …

Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with onset
usually in childhood characterized by inattention, impulsivity, and hyperactivity causing a …

Dilated cardiomyopathy (DCM) is typically defined by left ventricular dilation and systolic
dysfunction in the absence of a clear precipitant. Idiopathic disease is common; up to 50% of …