Dilated cardiomyopathy caused by mutations in LMNA, encoding A-type lamins (ie, LMNA
cardiomyopathy), is characterized by a left ventricle enlargement and ultimately results in …

The normal function of the heart relies on a series of complex metabolic processes
orchestrating the proper generation and use of energy. In this context, mitochondria serve a …

Background Hepatic alterations are common aftereffects of heart failure (HF) and ventricular
dysfunction. The prognostic value of liver injury markers derived from cardiac MRI studies in …

Familial cardiomyopathy is an inherited disease that affects the structure and function of
heart muscle and has an extreme range of phenotypes. Among the millions of affected …

Background Dilated cardiomyopathy (DCM) is a condition involving dilation of cardiac
chambers, which results in contraction impairment. Besides invasive and non-invasive …

Heart failure (HF) is a global public health threat affecting 26 million individuals worldwide
with an estimated prevalence increase of 46% by 2030. One of the main causes of HF and …

Background The whole exome sequencing (WES) with targeted gene analysis is an effective
diagnostic tool for cardiomyopathy. The early‐onset sudden cardiac death (SCD) was …

Tanshinol borneol ester (DBZ) exerts anti-atherosclerotic and anti-inflammatory effects.
However, its effects on cardiac hypertrophy are not well understood. In this work, we …

Abstract Aims Cardiomyopathies (CMPs) are a heterogeneous group of diseases that are
defined by structural and functional abnormalities of the cardiac muscle. Dilated …

Comprehensive detailed characterization of new mouse models can be challenging due to
the individual focus involved in developing these models. Often models are engineered to …