Background: Cardiomyopathies are a heterogeneous group of pathologies characterized by
structural and functional alterations of the heart. Aims: The purpose of this narrative review is …

Heart disease is the leading cause of death worldwide. Cardiomyopathy is a disease
characterized by the heart muscle damage, resulting heart in a structurally and functionally …

Dilated cardiomyopathy (DCM) is typically defined by left ventricular dilation and systolic
dysfunction in the absence of a clear precipitant. Idiopathic disease is common; up to 50% of …

Our insight into the diverse and complex nature of dilated cardiomyopathy (DCM) genetic
architecture continues to evolve rapidly. The foundations of DCM genetics rest on marked …

Small angle X-ray fiber diffraction is the method of choice for obtaining molecular level
structural information from striated muscle fibers under hydrated physiological conditions …

Cardiovascular diseases (CVDs) are the principal cause of disease burden and death
worldwide. Ferroptosis is a new form of regulated cell death mainly characterized by altered …

Alternative splicing, a driver of posttranscriptional variance, differs from canonical splicing by
arranging the introns and exons of an immature pre-mRNA transcript in a multitude of …

It has been nearly 15 years since the discovery of human-induced pluripotent stem cells
(iPSCs). During this time, differentiation methods to targeted cells have dramatically …

Dilated cardiomyopathy caused by mutations in LMNA, encoding A-type lamins (ie, LMNA
cardiomyopathy), is characterized by a left ventricle enlargement and ultimately results in …

In the forensic medicine field, molecular autopsy is the post-mortem genetic analysis
performed to attempt to unravel the cause of decease in cases remaining unexplained after …