One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

A discussion of the pathogenesis of type 2 diabetes mellitus must start with a review of
mechanisms involved in the maintenance of normal glucose homeostasis in the basal or …

Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To
identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic …

Type 2 diabetes is a progressive disease characterised by islet amyloid deposits in the
majority of patients. Amyloid formation is considered a significant factor in deterioration of …

Type 2 diabetes is associated with progressive β-cell failure manifest as a decline in insulin
secretion and increasing hyperglycemia. A growing body of evidence suggests that β-cell …

The role of islet amyloidosis in the onset and progression of Type 2 diabetes remains
obscure. Islet amyloid polypeptide is a 37 amino-acid, beta-cell peptide which is co-stored …

At least eight distinct pathophysiologic abnormalities have been associated with type 2
diabetes mellitus (T2DM). It is well established that decreased peripheral glucose uptake …

Pancreatic p-cells are strongly engagedin protein secretion and have highly developed
endoplasmic reticulum (ER). Proper folding of polypeptide into a threedimensional structure …

The formation of amyloid fibrils by the human islet amyloid polypeptide is associated with
type II diabetes. While it was previously suggested that the formed fibrils are toxic to …

Elevated oxidative capacity, such as occurs via endurance exercise training, is believed to
protect against the development of obesity and diabetes. Rats bred both for low (LCR)-and …