It is an urgent need that defect repair can develop from simple device fixation to living tissue
reconstruction, from short life function replacement to permanent regeneration repair. At …

Bone defects combined with tumors, infections, or other bone diseases are challenging in
clinical practice. Autologous and allogeneic grafts are two main traditional remedies, but …

Osteoporosis is a chronic disease characterized by low bone mass caused by increased
bone turnover and impaired bone microarchitecture. In treatment, we use antiresorptive or …

Natural bone tissue is composed of calcium-deficient carbonated hydroxyapatite as the
inorganic phase and collagen type I as the main organic phase. The biomimetic approach of …

The regulatory functions of the immune response in tissue healing, repair, and regeneration
have been evidenced in the last decade. Immune cells play central roles in immune …

Limited motor activity due to the loss of natural structure impedes recovery in patients
suffering from tendon-to-bone injury. Conventional biomaterials focus on strengthening the …

Extensive macrophage inflammatory responses and osteoclast formation are predominant
during inflammatory or infective osteolysis. Mesenchymal stem cell (MSC)-derived small …

In clinical treatment, the bone regeneration of critical‐size defects is desiderated to be
solved, and the regeneration of large bone segment defects depends on early …

Spatial dimension of pores and interconnection in macroporous scaffolds is of particular
importance in facilitating endogenous cell migration and bone tissue ingrowth. However, it is …

Tooth defect and loss are common clinical diseases in stomatology. With the extension of life
expectancy, there is an increasing demand for tooth tissue and whole tooth regeneration …