[HTML][HTML] Multitalented synthetic antimicrobial peptides and their antibacterial, antifungal and antiviral mechanisms

T Vanzolini, M Bruschi, AC Rinaldi, M Magnani… - International Journal of …, 2022 - mdpi.com
Despite the great strides in healthcare during the last century, some challenges still
remained unanswered. The development of multi-drug resistant bacteria, the alarming …

In pursuit of next-generation therapeutics: Antimicrobial peptides against superbugs, their sources, mechanism of action, nanotechnology-based delivery, and clinical …

A Thakur, A Sharma, HK Alajangi, PK Jaiswal… - International Journal of …, 2022 - Elsevier
Antimicrobial peptides (AMPs) attracted attention as potential source of novel antimicrobials.
Multi-drug resistant (MDR) infections have emerged as a global threat to public health in …

Secondary amine pendant β-peptide polymers displaying potent antibacterial activity and promising therapeutic potential in treating MRSA-induced wound infections …

Y Qian, S Deng, Z Cong, H Zhang, Z Lu… - Journal of the …, 2022 - ACS Publications
Interest in developing antibacterial polymers as synthetic mimics of host defense peptides
(HPDs) has accelerated in recent years to combat antibiotic-resistant bacterial infections …

Pharmaceutical nanotechnology: antimicrobial peptides as potential new drugs against WHO list of critical, high, and medium priority bacteria

CA Roque-Borda, PB Da Silva, MC Rodrigues… - European Journal of …, 2022 - Elsevier
Nanobiotechnology is a relatively unexplored area that has, nevertheless, shown relevant
results in the fight against some diseases. Antimicrobial peptides (AMPs) are …

Microbial Metabolite Inspired β‐Peptide Polymers Displaying Potent and Selective Antifungal Activity

D Zhang, C Shi, Z Cong, Q Chen, Y Bi… - Advanced …, 2022 - Wiley Online Library
Potent and selective antifungal agents are urgently needed due to the quick increase of
serious invasive fungal infections and the limited antifungal drugs available. Microbial …

Conditional Antimicrobial Peptide Therapeutics

C Ngambenjawong, LW Chan, HE Fleming… - ACS nano, 2022 - ACS Publications
Antimicrobial peptides (AMPs) constitute a promising class of alternatives to antibiotics to
curb antimicrobial resistance. Nonetheless, their utility as a systemic agent is hampered by …

A Janus Au–Polymersome Heterostructure with Near‐Field Enhancement Effect for Implant‐Associated Infection Phototherapy

C Chen, G Chu, W He, Y Liu, K Dai, J Valdez… - Advanced …, 2023 - Wiley Online Library
Polymer–inorganic hybrid Janus nanoparticles (PI‐JNPs) have attracted extensive attention
due to their special structures and functions. However, achieving the synergistic …

Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens

B Lin, A Hung, R Li, A Barlow, W Singleton… - European Journal of …, 2022 - Elsevier
Abstract The World Health Organisation has deemed several multi-drug resistant (MDR)
nosocomial bacterial pathogens to be of significant threat to human health. A stark increase …

Antimicrobial peptides/ciprofloxacin-loaded O-carboxymethyl chitosan/self-assembling peptides hydrogel dressing with sustained-release effect for enhanced anti …

Y Huan, Q Kong, Q Tang, Y Wang, H Mou, R Ying… - Carbohydrate …, 2022 - Elsevier
Bacteria-induced wound infections and multifunctional hydrogels have received widespread
attention in wound repair. In this study, self-assembling peptides (SAPs) were grafted on O …

[HTML][HTML] Host defense peptide-mimicking polymers and polymeric-brush-tethered host defense peptides: recent developments, limitations, and potential success

H Etayash, REW Hancock - Pharmaceutics, 2021 - mdpi.com
Amphiphilic antimicrobial polymers have attracted considerable interest as structural mimics
of host defense peptides (HDPs) that provide a broad spectrum of activity and do not induce …