Fluoroamphiphilic polymers exterminate multidrug-resistant Gram-negative ESKAPE pathogens while attenuating drug resistance

Q Zhou, K Li, K Wang, W Hong, J Chen, J Chai… - Science …, 2024 - science.org
ESKAPE pathogens are a panel of most recalcitrant bacteria that could “escape” the
treatment of antibiotics and exhibit high incidence of drug resistance. The emergence of …

Innovative strategies to overcome antimicrobial resistance and tolerance

MI Choudhary, U Römling, F Nadeem, HM Bilal… - Microorganisms, 2022 - mdpi.com
Antimicrobial resistance and tolerance are natural phenomena that arose due to
evolutionary adaptation of microorganisms against various xenobiotic agents. These …

Outer-Membrane Permeabilization, LPS Transport Inhibition: Activity, Interactions, and Structures of Thanatin Derived Antimicrobial Peptides

SJ Abdullah, BTS Yan, N Palanivelu… - International Journal of …, 2024 - mdpi.com
Currently, viable antibiotics available to mitigate infections caused by drug-resistant Gram-
negative bacteria are highly limited. Thanatin, a 21-residue-long insect-derived antimicrobial …

Imaging biomolecules in bilayers supported at electrode surfaces

P Pieta, S Sek, J Lipkowski - Current Opinion in Electrochemistry, 2023 - Elsevier
This short review describes our efforts to apply scanning tunneling microscopy and atomic
force microscopy to provide an understanding of the mechanism of phospholipid bilayer …

Enhanced synergistic antibacterial and antibiofilm efficacy of main-chain polysulfoniums with antibiotics by balancing charge density and amphiphilicity

Y Zhao, X Wang, Y Hu, J Zhao, M Sun… - ACS Applied Polymer …, 2023 - ACS Publications
Infection diseases caused by Gram-negative pathogens are exceedingly difficult to treat
because their characteristic outer membrane limits antibiotic entry. Herein, we report the …

[HTML][HTML] The natriuretic peptide receptor agonist osteocrin disperses Pseudomonas aeruginosa biofilm

M Louis, A Tahrioui, CJ Tremlett, T Clamens… - Biofilm, 2023 - Elsevier
Biofilms are highly tolerant to antimicrobials and host immune defense, enabling pathogens
to thrive in hostile environments. The diversity of microbial biofilm infections requires …

The antimicrobial peptide Esc(1-21)-1c increases susceptibility of Pseudomonas aeruginosa to conventional antibiotics by decreasing the expression of the MexAB …

C Canè, B Casciaro, A Di Somma, MR Loffredo… - Frontiers in …, 2023 - frontiersin.org
Introduction: The increase in bacterial strains resistant to conventional antibiotics is an
alarming problem for human health and could lead to pandemics in the future. Among …

Discovery and Characterization of a New Crustin Antimicrobial Peptide from Amphibalanus amphitrite

W Zhang, X Xu, J Zhang, T Ye, Q Zhou, Y Xu, W Li… - Pharmaceutics, 2022 - mdpi.com
Crustins are an antimicrobial peptide (AMP) family that plays an important role in innate
immunity in crustaceans. It is important to discover new AMPs from natural sources to …

Activities of a broad‐spectrum antimicrobial peptide analogue SAMP‐A4‐C8 and its combat against pneumonia in Staphylococcus aureus‐infected mice

R Li, P Hao, K Yin, Q Xu, S Ren, Y Zhao… - Journal of Peptide …, 2023 - Wiley Online Library
Antimicrobial peptides and their analogues have become substitutes for antibiotics in recent
years. The antimicrobial peptide analogue SAMP‐A4‐C8 (n‐octanoic‐VRLLRRRI) with high …

Novel alligator cathelicidin As-CATH8 demonstrates anti-infective activity against clinically relevant and crocodylian bacterial pathogens

FL Santana, K Estrada, MA Alford, BC Wu, M Dostert… - Antibiotics, 2022 - mdpi.com
Host defense peptides (HDPs) represent an alternative way to address the emergence of
antibiotic resistance. Crocodylians are interesting species for the study of these molecules …