Novel and emerging treatments for major depression

S Marwaha, E Palmer, T Suppes, E Cons, AH Young… - The Lancet, 2023 - thelancet.com
Depression is common, costly, debilitating, and associated with increased risk of suicide. It is
one of the leading global public health problems. Although existing available …

Machine learning in the prediction of depression treatment outcomes: a systematic review and meta-analysis

M Sajjadian, RW Lam, R Milev, S Rotzinger… - Psychological …, 2021 - cambridge.org
Background Multiple treatments are effective for major depressive disorder (MDD), but the
outcomes of each treatment vary broadly among individuals. Accurate prediction of …

The promise of machine learning in predicting treatment outcomes in psychiatry

AM Chekroud, J Bondar, J Delgadillo… - World …, 2021 - Wiley Online Library
For many years, psychiatrists have tried to understand factors involved in response to
medications or psychotherapies, in order to personalize their treatment choices. There is …

[HTML][HTML] Identifying transdiagnostic mechanisms in mental health using computational factor modeling

T Wise, OJ Robinson, CM Gillan - Biological Psychiatry, 2023 - Elsevier
Most psychiatric disorders do not occur in isolation, and most psychiatric symptom
dimensions are not uniquely expressed within a single diagnostic category. Current …

[HTML][HTML] Randomized controlled trials of artificial intelligence in clinical practice: systematic review

TYT Lam, MFK Cheung, YL Munro, KM Lim… - Journal of Medical …, 2022 - jmir.org
Background The number of artificial intelligence (AI) studies in medicine has exponentially
increased recently. However, there is no clear quantification of the clinical benefits of …

Heterogeneity of treatment effects in trials on psychotherapy of depression.

T Kaiser, C Volkmann, A Volkmann… - … Science and Practice, 2022 - psycnet.apa.org
Practitioners and researchers alike assume that there is individual variability in the effects of
treatments for mental disorders. However, for psychotherapy, up to now this assumption has …

Predicting treatment outcome in depression: an introduction into current concepts and challenges

N Rost, EB Binder, TM Brückl - European Archives of Psychiatry and …, 2023 - Springer
Improving response and remission rates in major depressive disorder (MDD) remains an
important challenge. Matching patients to the treatment they will most likely respond to …

Real-world implementation of precision psychiatry: A systematic review of barriers and facilitators

H Baldwin, L Loebel-Davidsohn, D Oliver… - Brain sciences, 2022 - mdpi.com
Background: Despite significant research progress surrounding precision medicine in
psychiatry, there has been little tangible impact upon real-world clinical care. Objective: To …

Effectiveness of common antidepressants: a post market release study

F Alemi, H Min, M Yousefi, LK Becker, CA Hane… - …, 2021 - thelancet.com
Background This study summarizes the experiences of patients, who have multiple
comorbidities, with 15 mono-treated antidepressants. Methods This is a retrospective …

[HTML][HTML] Patient-reported outcome measures for monitoring primary care patients with depression: the PROMDEP cluster RCT and economic evaluation.

T Kendrick, C Dowrick, G Lewis, M Moore… - Health Technology …, 2024 - ncbi.nlm.nih.gov
BACKGROUND Guidelines on the management of depression recommend that practitioners
use patient-reported outcome measures for the follow-up monitoring of symptoms, but there …