Introduction: Developing in vitro models for studying cell biology and cell physiology is of
great importance to the fields of biotechnology, cancer research, drug discovery, toxicity …

Moving from cell monolayers to three-dimensional (3D) cultures is motivated by the need to
work with cellular models that mimic the functions of living tissues. Essential cellular …

随着复杂系统诊断, 预测和系统健康管理技术的不断发展, 在新兴的工业信息系统和工业智能的
推动下, 数字孪生技术成为智能制造领域和复杂系统智能运行和维护领域的新兴研究热点 …

Most cancers in humans are large, measuring centimetres in diameter, and composed of
many billions of cells. An equivalent mass of normal cells would be highly heterogeneous as …

Many types of mammalian cells can aggregate and differentiate into 3‐D multicellular
spheroids when cultured in suspension or a nonadhesive environment. Compared to …

The availability and utility of genome‐scale metabolic reconstructions have exploded since
the first genome‐scale reconstruction was published a decade ago. Reconstructions have …

Tumors are being increasingly perceived as abnormal organs that, in many respects,
recapitulate the outgrowth and differentiation patterns of normal tissues. In line with this idea …

Despite major scientific, medical and technological advances over the last few decades, a
cure for cancer remains elusive. The disease initiation is complex, and including initiation …

This Timeline article charts progress in mathematical modelling of cancer over the past 50
years, highlighting the different theoretical approaches that have been used to dissect the …

This is the first paper in a two-part series in which we develop, analyze, and simulate a
diffuse interface continuum model of multispecies tumor growth and tumor-induced …