Cancer ranks among the top causes of mortality on a global scale. The only treatments
available for cancer nowadays are surgery, radiation therapy, and the use of cytotoxic …

Metal-based drugs hold promise as potent anticancer agents owing to their unique
interactions with cellular targets. This review discusses recent advances in our …

Doxorubicin (Dox) is an effective anticancer molecule, but its clinical efficacy is limited by
strong cardiotoxic side effects. Lysosomal dysfunction has recently been proposed as a new …

Developing effective near-infrared (NIR) photosensitizers (PSs) has been an attractive goal
of photodynamic therapy (PDT) for cancer treatment. In this study, we synthesized N, N …

Contemporary progress in tumor immunotherapy has solidified its role as an effective
approach in combating cancer. Nonetheless, the prevalent “immune cold” state within the …

Graphene-based nanomaterials (GNMs), including graphene, graphene oxide, reduced
graphene oxide, and graphene quantum dots, may have direct anticancer activity or be used …

This short note presents the data and rationale for adding five generic non-oncology drugs
from general medical practice to gemcitabine, nab-paclitaxel, a current standard cytotoxic …

Induced lysosomal membrane permeabilization (LMP) by peptide self-assembly has
emerged as an effective platform for lysosome-targeted cancer therapy. In this study, we shift …

The reactive nitrogen species (RNS) in lysosomes play a major role during the regulation of
lysosomal microenvironment. Nitroxyl (HNO) belongs to active nitrogen species (RNS) and …

Aim: Lysosomal pH changes are associated with drug resistance, cell growth and invasion
of tumors, but effective and specific real-time monitoring of lysosomal pH compounds for …