Revolutionizing anticancer treatment: Ruthenium-based nanoplatforms pave new paths
D Karati, S Meur, S Mukherjee, S Roy - Coordination Chemistry Reviews, 2024 - Elsevier
Cancer ranks among the top causes of mortality on a global scale. The only treatments
available for cancer nowadays are surgery, radiation therapy, and the use of cytotoxic …
available for cancer nowadays are surgery, radiation therapy, and the use of cytotoxic …
A review on the recent advances of interaction studies of anticancer metal-based drugs with therapeutic targets, DNA and RNAs
HY Khan, MF Ansari, S Tabassum, F Arjmand - Drug Discovery Today, 2024 - Elsevier
Metal-based drugs hold promise as potent anticancer agents owing to their unique
interactions with cellular targets. This review discusses recent advances in our …
interactions with cellular targets. This review discusses recent advances in our …
[HTML][HTML] Inhalation of acidic nanoparticles prevents doxorubicin cardiotoxicity through improvement of lysosomal function
Y Santin, K Formoso, F Haidar, MDPO Fuentes… - Theranostics, 2023 - ncbi.nlm.nih.gov
Doxorubicin (Dox) is an effective anticancer molecule, but its clinical efficacy is limited by
strong cardiotoxic side effects. Lysosomal dysfunction has recently been proposed as a new …
strong cardiotoxic side effects. Lysosomal dysfunction has recently been proposed as a new …
Lysosome-targeted Aza-BODIPY photosensitizers for anti-cancer photodynamic therapy
M Hu, X Dong, W Zhao - Bioorganic & Medicinal Chemistry, 2024 - Elsevier
Developing effective near-infrared (NIR) photosensitizers (PSs) has been an attractive goal
of photodynamic therapy (PDT) for cancer treatment. In this study, we synthesized N, N …
of photodynamic therapy (PDT) for cancer treatment. In this study, we synthesized N, N …
[HTML][HTML] Applications of Pyroptosis Activators in Tumor Immunotherapy
X Bao, M Sun, L Meng, H Zhang, X Yi, P Zhang - Materials Today Bio, 2024 - Elsevier
Contemporary progress in tumor immunotherapy has solidified its role as an effective
approach in combating cancer. Nonetheless, the prevalent “immune cold” state within the …
approach in combating cancer. Nonetheless, the prevalent “immune cold” state within the …
The Exploitation of Lysosomes in Cancer Therapy with Graphene-Based Nanomaterials
B Ristic, M Bosnjak, M Misirkic Marjanovic… - Pharmaceutics, 2023 - mdpi.com
Graphene-based nanomaterials (GNMs), including graphene, graphene oxide, reduced
graphene oxide, and graphene quantum dots, may have direct anticancer activity or be used …
graphene oxide, and graphene quantum dots, may have direct anticancer activity or be used …
[HTML][HTML] IPIAD-an augmentation regimen added to standard treatment of pancreatic ductal adenocarcinoma using already-marketed repurposed drugs irbesartan …
RE Kast - Oncoscience, 2024 - ncbi.nlm.nih.gov
This short note presents the data and rationale for adding five generic non-oncology drugs
from general medical practice to gemcitabine, nab-paclitaxel, a current standard cytotoxic …
from general medical practice to gemcitabine, nab-paclitaxel, a current standard cytotoxic …
Acid-assisted self-assembly of pyrene-capped tyrosine ruptures lysosomes to induce cancer cell apoptosis
J Li, J Song, L Shao, X Zhang, Z Wang, G Li, J Wang… - RSC …, 2024 - pubs.rsc.org
Induced lysosomal membrane permeabilization (LMP) by peptide self-assembly has
emerged as an effective platform for lysosome-targeted cancer therapy. In this study, we shift …
emerged as an effective platform for lysosome-targeted cancer therapy. In this study, we shift …
A rhodamine-based fluorescent probe used to determine nitroxyl (HNO) in lysosomes
S Liu, J Xu, Q Ma, L Li, G Mao, G Wang, X Wu - Analytical Biochemistry, 2024 - Elsevier
The reactive nitrogen species (RNS) in lysosomes play a major role during the regulation of
lysosomal microenvironment. Nitroxyl (HNO) belongs to active nitrogen species (RNS) and …
lysosomal microenvironment. Nitroxyl (HNO) belongs to active nitrogen species (RNS) and …
Palbociclib-derived multifunctional molecules for lysosomal targeting and diagnostic-therapeutic integration
H Yang, X Zhang, L Xu, Y Zhou, R Ma… - Future Medicinal …, 2024 - Taylor & Francis
Aim: Lysosomal pH changes are associated with drug resistance, cell growth and invasion
of tumors, but effective and specific real-time monitoring of lysosomal pH compounds for …
of tumors, but effective and specific real-time monitoring of lysosomal pH compounds for …