The highly diverse antiphage defence systems of bacteria
H Georjon, A Bernheim - Nature Reviews Microbiology, 2023 - nature.com
Bacteria and their viruses have coevolved for billions of years. This ancient and still ongoing
arms race has led bacteria to develop a vast antiphage arsenal. The development of high …
arms race has led bacteria to develop a vast antiphage arsenal. The development of high …
The arms race between bacteria and their phage foes
HG Hampton, BNJ Watson, PC Fineran - Nature, 2020 - nature.com
Bacteria are under immense evolutionary pressure from their viral invaders—
bacteriophages. Bacteria have evolved numerous immune mechanisms, both innate and …
bacteriophages. Bacteria have evolved numerous immune mechanisms, both innate and …
Carbon-to-nitrogen single-atom transmutation of azaarenes
J Woo, C Stein, AH Christian, MD Levin - Nature, 2023 - nature.com
When searching for the ideal molecule to fill a particular functional role (for example, a
medicine), the difference between success and failure can often come down to a single …
medicine), the difference between success and failure can often come down to a single …
Identification and classification of antiviral defence systems in bacteria and archaea with PADLOC reveals new system types
To provide protection against viral infection and limit the uptake of mobile genetic elements,
bacteria and archaea have evolved many diverse defence systems. The discovery and …
bacteria and archaea have evolved many diverse defence systems. The discovery and …
A decade of discovery: CRISPR functions and applications
R Barrangou, P Horvath - Nature microbiology, 2017 - nature.com
This year marks the tenth anniversary of the identification of the biological function of
CRISPR–Cas as adaptive immune systems in bacteria. In just a decade, the characterization …
CRISPR–Cas as adaptive immune systems in bacteria. In just a decade, the characterization …
Precise DNA cleavage using CRISPR-SpRYgests
Methods for in vitro DNA cleavage and molecular cloning remain unable to precisely cleave
DNA directly adjacent to bases of interest. Restriction enzymes (REs) must bind specific …
DNA directly adjacent to bases of interest. Restriction enzymes (REs) must bind specific …
[HTML][HTML] The epigenomic landscape of prokaryotes
DNA methylation acts in concert with restriction enzymes to protect the integrity of
prokaryotic genomes. Studies in a limited number of organisms suggest that methylation …
prokaryotic genomes. Studies in a limited number of organisms suggest that methylation …
Site-selective photoinduced cleavage and profiling of DNA by chiral semiconductor nanoparticles
M Sun, L Xu, A Qu, P Zhao, T Hao, W Ma, C Hao… - Nature …, 2018 - nature.com
Gene editing is an important genetic engineering technique that enables gene manipulation
at the molecular level. It mainly relies on engineered nucleases of biological origin, whose …
at the molecular level. It mainly relies on engineered nucleases of biological origin, whose …
The interplay of restriction-modification systems with mobile genetic elements and their prokaryotic hosts
The roles of restriction-modification (RM) systems in providing immunity against horizontal
gene transfer (HGT) and in stabilizing mobile genetic elements (MGEs) have been much …
gene transfer (HGT) and in stabilizing mobile genetic elements (MGEs) have been much …