Background: The blood–brain barrier acts as a highly regulated interface; its dysfunction
may exacerbate, and perhaps initiate, neurological and neuropsychiatric disorders …

The concept of “aging” is defined as the set of gradual and progressive changes in an
organism that leads to an increased risk of weakness, disease, and death. This process may …

Background Oxidative stress, defined as an imbalance between pro-oxidants and
neutralizing antioxidants within the body, is a growing public health concern. Oxidative …

The evolutionarily ancient methoxyindoleamine, melatonin, has long perplexed investigators
by its versatility of functions and mechanisms of action, which include the regulation of …

Ovarian cancer (OC) is the most lethal gynecologic malignancy, and melatonin has shown
various antitumor properties. Herein, we investigated the influence of melatonin therapy on …

From an evolutionary point of view, vitamin D and melatonin appeared very early and share
functions related to defense mechanisms. In the current clinical setting, vitamin D is …

The last four decades, we assist to an increasing scientific interest on melatonin, a circadian
hormone, a metabolic regulator which influences not only plants' metabolism and their …

Cancer is a death cause in economically developed countries that results growing also in
developing countries. Improved outcome through targeted interventions faces the scarce …

It is widely known that lack of sleep damages the skin. Therefore, it is necessary to explore
the relationship between sleep deprivation and skin damage and to find effective treatments …

Abstract Purpose of Review Here, we review the known relations between hypertension and
obesity to inflammation and postulate the endogenous protective effect of melatonin and its …