A radical is any molecule that contains one or more unpaired electrons. Radicals are normal
products of many metabolic pathways. Some exist in a controlled (caged) form as they …

Chronic obstructive pulmonary disease (COPD) includes chronic bronchitis and
emphysema. Environmental exposure, primarily cigarette smoking, can cause high oxidative …

Hyperoxia increases reactive oxygen species (ROS) production in vascular endothelium;
however, the mechanisms involved in ROS generation are not well characterized. We …

1. Tissue-specific profiles of the expression of the antioxidant enzymes superoxide
dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) and the …

Radiation therapy (RT) is an important therapeutic modality in the treatment of thoracic
tumors. The maximum doses to these tumors are often limited by the radiation tolerance of …

Abstract Epperly, MW, Gretton, JA, DeFilippi, SJ, Sikora, CA, Liggitt, D., Koe, G. and
Greenberger, JS Modulation of Radiation-Induced Cytokine Elevation Associated with …

PURPOSE: The purpose of this study was to determine if radiation-induced lung injury is
associated with prolonged oxidative stress, and whether chronic overexpression of …

Nitric oxide (NO) and other reactive nitrogen species target multiple sites in the mitochondria
to influence cellular bioenergetics and survival. Kinetic imaging studies revealed that NO …

Purpose: A dose and volume limiting factor in radiation treatment of thoracic cancer is the
development of fibrosis in normal lung. The goal of the present study was to determine …

Because antioxidant enzymes may have an important role in the oxidant resistance of
inflammatory cells, we investigated the mRNA levels and specific activities of manganese …