With recent advances in high-throughput next-generation sequencing, it is possible to
describe the regulation and expression of genes at multiple levels. An assay for transposase …

The Hi-C technique has been shown to be a promising method to detect structural variations
(SVs) in human genomes. However, algorithms that can use Hi-C data for a full-range SV …

Zebrafish, a popular organism for studying embryonic development and for modeling human
diseases, has so far lacked a systematic functional annotation program akin to those in other …

Methylation of cytosines is a prototypic epigenetic modification of the DNA. It has been
implicated in various regulatory mechanisms across the animal kingdom and particularly in …

Regulatory landscapes drive complex developmental gene expression, but it remains
unclear how their integrity is maintained when incorporating novel genes and functions …

There is considerable interest in understanding the effect of transposable elements (TEs) on
embryonic development. Studies in humans and mice are limited by the difficulty of working …

Currently, the dynamic accessible elements that determine regulatory programs responsible
for the unique identity and function of each cell type during zebrafish embryogenesis lack …

Cardiogenesis is a tightly regulated dynamic process through a continuum of differentiation
and proliferation events. Key factors and pathways governing this process remain …

Chromatin architecture mapping in 3D formats has increased our understanding of how
regulatory sequences and gene expression are connected and regulated in a genome. The …

Acute trauma stimulates local repair mechanisms but can also impact structures distant from
the injury, for example through the activity of circulating factors. To study the responses of …