Myocardial repair/remodelling following infarction: roles of local factors
Y Sun - Cardiovascular research, 2009 - academic.oup.com
Heart failure is a global health problem, appearing most commonly in patients with previous
myocardial infarction (MI). Cardiac remodelling, particularly fibrosis, seen in both the …
myocardial infarction (MI). Cardiac remodelling, particularly fibrosis, seen in both the …
Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism
JP Habashi, JJ Doyle, TM Holm, H Aziz, F Schoenhoff… - Science, 2011 - science.org
Angiotensin II (AngII) mediates progression of aortic aneurysm, but the relative contribution
of its type 1 (AT1) and type 2 (AT2) receptors remains unknown. We show that loss of AT2 …
of its type 1 (AT1) and type 2 (AT2) receptors remains unknown. We show that loss of AT2 …
Blockade of the renin–angiotensin–aldosterone system: a key therapeutic strategy to reduce renal and cardiovascular events in patients with diabetes
M Burnier, A Zanchi - Journal of hypertension, 2006 - journals.lww.com
Diabetes (particularly type 2 diabetes) represents a global health problem of epidemic
proportions. Individuals with diabetes are not only more likely to develop hypertension …
proportions. Individuals with diabetes are not only more likely to develop hypertension …
Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat
The early and long-term effects of coronary artery ligation on the plasma and left ventricular
angiotensin-converting enzyme (ACE and ACE2) activities, ACE and ACE2 mRNA levels …
angiotensin-converting enzyme (ACE and ACE2) activities, ACE and ACE2 mRNA levels …
Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury
T Li, B Yu, Z Liu, J Li, M Ma, Y Wang, M Zhu… - Nature …, 2018 - nature.com
Hyperhomocysteinemia (HHcy) is a risk factor for various cardiovascular diseases. However,
the mechanism underlying HHcy-aggravated vascular injury remains unclear. Here we show …
the mechanism underlying HHcy-aggravated vascular injury remains unclear. Here we show …
Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor–dependent pathway that increases calcineurin degradation
C Donaldson, S Eder, C Baker, MJ Aronovitz… - Circulation …, 2009 - Am Heart Assoc
Left ventricular (LV) hypertrophy commonly develops in response to chronic hypertension
and is a significant risk factor for heart failure and death. The serine-threonine phosphatase …
and is a significant risk factor for heart failure and death. The serine-threonine phosphatase …
Vascular smooth muscle mineralocorticoid receptor contributes to coronary and left ventricular dysfunction after myocardial infarction
A Gueret, N Harouki, J Favre, G Galmiche, L Nicol… - …, 2016 - Am Heart Assoc
Mineralocorticoid receptor (MR) antagonists slow down the progression of heart failure after
myocardial infarction (MI), but the cell-specific role of MR in these benefits is unclear. In this …
myocardial infarction (MI), but the cell-specific role of MR in these benefits is unclear. In this …
Involvement of the Serotonin 5-HT2B Receptor in Cardiac Hypertrophy Linked to Sympathetic Stimulation: Control of Interleukin-6, Interleukin-1β, and Tumor Necrosis …
F Jaffré, J Callebert, A Sarre, N Etienne, CG Nebigil… - Circulation, 2004 - Am Heart Assoc
Background—The serotonergic 5-HT2B receptor regulates cardiomyocyte development and
growth. A putative contribution of this receptor to fibroblast-dependent cardiac function has …
growth. A putative contribution of this receptor to fibroblast-dependent cardiac function has …
[HTML][HTML] Early administration of empagliflozin preserved heart function in cardiorenal syndrome in rat
CC Yang, YT Chen, CG Wallace, KH Chen… - Biomedicine & …, 2019 - Elsevier
This study tested the hypothesis that early administration of empagliflozin (Empa), an
inhibitor of glucose recycling in renal tubules, could preserve heart function in cardiorenal …
inhibitor of glucose recycling in renal tubules, could preserve heart function in cardiorenal …
Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid β-protein metabolism in mouse models of Alzheimer disease
ML Hemming, DJ Selkoe, W Farris - Neurobiology of disease, 2007 - Elsevier
Genetic and pathologic studies have associated angiotensin-converting enzyme (ACE) with
Alzheimer disease. Previously, we and others have reported that ACE degrades in vitro the …
Alzheimer disease. Previously, we and others have reported that ACE degrades in vitro the …