In the current era, an ever-emerging threat of multidrug-resistant (MDR) pathogens pose
serious health challenges to mankind. Researchers are uninterruptedly putting their efforts …

Highlights•Therapeutic management of tauopathies of major public health
interest.•Complexity of interaction with the tau protein related to its structural …

Some metabolic enzyme inhibitors can be used as Multi-target-Directed-Ligands (MTDL) in
Medicinal chemistry therefore, synthesis and determination of alternative inhibitors are …

Invasive species are a major threat for native ecosystems and organisms living within. They
are reducing the biodiversity in invaded ecosystems, by outcompeting native species with eg …

New benzimidazolium salts were synthesized as N-heterocyclic carbene precursors. These
NHC precursors were metallated with Cu2O and CuI in acetone and water under reflux to …

A series of [RuCl2 (p-cymene)(NHC)] complexes were obtained by reacting [RuCl2 (p-
cymene)] 2 with in situ generated Ag-N-heterocyclic carbene (NHC) complexes. The …

Background: Naphthoquinones are a class of aromatic compounds relevant for their
chemical characteristics, structural properties, and biological activity. These compounds are …

Quinones are attractive pharmacological scaffolds for developing new agents for the
treatment of different transmissible and non-transmissible human diseases due to their …

Alzheimer's disease is a neurodegenerative disorder that deteriorates mental ability. Two
main cholinesterases named, acetylcholinesterase and butyrylcholinesterase are potential …

The aim of this study was devoted into molecular docking calculations to discover the
potential antileishmania and antitoxoplasma activities of newly synthesized compounds …