During the last decade, a host of epigenetic mechanisms were found to contribute to cancer
and other human diseases. Several genomic studies have revealed that∼ 20% of …

Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of
genetic information from DNA to proteins by expanding the coding capacity of genomes …

Pre-mRNA maturation frequently occurs at the same time and place as transcription by RNA
polymerase II. The co-transcriptionality of mRNA processing has permitted the evolution of …

Alternative splicing plays critical roles in differentiation, development, and disease and is a
major source for protein diversity in higher eukaryotes. Analysis of alternative splicing …

The transcription factor Foxp3 is indispensible for the differentiation and function of
regulatory T cells (Treg cells). To gain insights into the molecular mechanisms of Foxp3 …

Core RNA-processing reactions in eukaryotic cells occur cotranscriptionally in a chromatin
context, but the relationship between chromatin structure and pre-mRNA processing is …

Pre-messenger RNAs (pre-mRNAs) maturation is initiated cotranscriptionally. It is therefore
conceivable that chromatin-borne information participates in alternative splicing. Here we …

RNA synthesis by RNA polymerase II and RNA processing are closely coupled during the
transcription cycle of protein‐coding genes. This coupling affords opportunities for quality …

Chromatin remodelling factors (CHRs) typically function to alter chromatin structure. CHRs
also reside in ribonucleoprotein complexes, but little is known about their RNA-related …

There is increasing evidence to suggest that splicing decisions are largely made when the
nascent RNA is still associated with chromatin. Here we demonstrate that activity of histone …