Unraveling the gene expression networks governing cancer initiation and development is
essential while remains largely uncompleted. With the innovations in RNA-seq technologies …

Systematic studies of the cancer genome have exploded in recent years. These studies
have revealed scores of new cancer genes, including many in processes not previously …

The discovery of numerous noncoding RNA (ncRNA) transcripts in species from yeast to
mammals has dramatically altered our understanding of cell biology, especially the biology …

" The definitive reference for budding and experienced cancer epidemiologists alike."-
American Journal of Epidemiology" Practitioners in epidemiology and oncology will find …

Over 1.66 million humans (approx. 500/100 000 population rate) and over 4.2 million dogs
(approx. 5300/100 000 population rate) are diagnosed with cancer annually in the USA. The …

Recent advances in genome sequencing technologies provide unprecedented opportunities
to characterize individual genomic landscapes and identify mutations relevant for diagnosis …

All malignant cancers, whether inherited or sporadic, are fundamentally governed by
Darwinian dynamics. The process of carcinogenesis requires genetic instability and highly …

Genome-wide association studies (GWASs) have been heralded as a major advance in
biomedical discovery, having identified~ 2,000 robust associations with complex diseases …

Pooling genome-wide association studies (GWASs) increases power but also poses
methodological challenges because studies are often heterogeneous. For example …

Deciphering the ways in which somatic mutations and germline susceptibility variants
cooperate to promote cancer is challenging. Ewing sarcoma is characterized by fusions …