The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell
proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy …

The development of combination immunotherapy based on the mediation of regulatory
mechanisms of the tumor immune microenvironment (TIME) is promising. However, a deep …

Iron is an essential trace element for the human body, and its deficiency or excess can
induce a variety of biological processes. Plenty of evidences have shown that iron …

Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is
limited due to the metastasis of cells to distant locations of the body through the blood and …

Background Gastric cancer stem cells (CSCs) are the main causes of metastasis and drug
resistance. We previously indicated that miR-375 can inhibit Helicobacter pylori-induced …

Triple-negative breast cancer (TNBC) is the most complex, aggressive and fatal subtype of
breast cancer. Owing to the lack of targeted therapy and heterogenic nature of TNBC …

Breast cancer is the second common cancer and the leading cause of malignancy among
females overall. Breast cancer stem cells (BCSCs) are a small population of breast cancer …

Multidrug resistance (MDR) of cancer is a persistent problem in chemotherapy. Scientists
have considered the overexpressed efflux transporters responsible for MDR and …

The E2F family of transcription factors (E2Fs) consist of eight genes in mammals. These
genes encode ten proteins that are usually classified as transcriptional activators or …

Tanshinone IIA is the active constituent extracted from Salvia Miltiorrhza. Numerous studies
have shown that Tanshinone IIA could inhibit tumor proliferation and metastasis, including …