Mitochondrial dysfunction in microglia: A novel perspective for pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly
globally. Emerging evidence has demonstrated microglia-driven neuroinflammation as a key …
globally. Emerging evidence has demonstrated microglia-driven neuroinflammation as a key …
A review of the current mammalian models of Alzheimer's disease and challenges that need to be overcome
NE Mckean, RR Handley, RG Snell - International journal of molecular …, 2021 - mdpi.com
Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing
lifespans and better medical treatment for other conditions mean that the prevalence of this …
lifespans and better medical treatment for other conditions mean that the prevalence of this …
Alzheimer's disease beyond amyloid: Can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery?
K Mullane, M Williams - Biochemical pharmacology, 2020 - Elsevier
Alzheimer's Disease (AD) therapeutics based on the amyloid hypothesis have repeatedly
failed in clinical trials. Together with numerous reports that amyloid is present in brains from …
failed in clinical trials. Together with numerous reports that amyloid is present in brains from …
Animal models of neurodegenerative disease: Recent advances in fly highlight innovative approaches to drug discovery
JA Tello, HE Williams, RM Eppler… - Frontiers in molecular …, 2022 - frontiersin.org
Neurodegenerative diseases represent a formidable challenge to global health. As
advances in other areas of medicine grant healthy living into later decades of life, aging …
advances in other areas of medicine grant healthy living into later decades of life, aging …
The amyloid precursor protein: A converging point in Alzheimer's disease
The decades of evidence that showcase the role of amyloid precursor protein (APP), and its
fragment amyloidβ (Aβ), in Alzheimer's disease (AD) pathogenesis are irrefutable. However …
fragment amyloidβ (Aβ), in Alzheimer's disease (AD) pathogenesis are irrefutable. However …
What's that (blue) spot on my MRI? Multimodal neuroimaging of the locus coeruleus in neurodegenerative disease
The locus coeruleus (LC) has long been underappreciated for its role in the pathophysiology
of Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative …
of Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative …
All roads lead to heterogeneity: the complex involvement of astrocytes and microglia in the pathogenesis of Alzheimer's disease
MK St-Pierre, J VanderZwaag, S Loewen… - Frontiers in Cellular …, 2022 - frontiersin.org
In recent years, glial cells have been acknowledged as key players in the pathogenesis of
Alzheimer's disease (AD), a neurodegenerative condition in which an accumulation of …
Alzheimer's disease (AD), a neurodegenerative condition in which an accumulation of …
Exploring advancements in early detection of Alzheimer's disease with molecular assays and animal models
Alzheimer's Disease (AD) is a challenging neurodegenerative condition, with overwhelming
implications for affected individuals and healthcare systems worldwide. Animal models have …
implications for affected individuals and healthcare systems worldwide. Animal models have …
ADVANCES IN ALZHEIMER'S DISEASE: A MULTIFACETED REVIEW OF POTENTIAL THERAPIES AND DIAGNOSTIC TECHNIQUES FOR EARLY DETECTION
M Sharma, P Pal, SK Gupta - Neurochemistry International, 2024 - Elsevier
Alzheimer's disease (AD) remains one of the most formidable neurological disorders,
affecting millions globally. This review provides a holistic overview of the therapeutic …
affecting millions globally. This review provides a holistic overview of the therapeutic …
Cognitive Deficits and Alzheimer's Disease-Like Pathologies in the Aged Chinese Tree Shrew
H Li, BL Xiang, X Li, C Li, Y Li, Y Miao, GL Ma… - Molecular …, 2024 - Springer
Alzheimer's disease (AD) is the most common chronic progressive neurodegenerative
disease in the elderly. It has an increasing prevalence and a growing health burden. One of …
disease in the elderly. It has an increasing prevalence and a growing health burden. One of …