Mitochondrial dysfunction in microglia: A novel perspective for pathogenesis of Alzheimer's disease

Y Li, X Xia, Y Wang, JC Zheng - Journal of neuroinflammation, 2022 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly
globally. Emerging evidence has demonstrated microglia-driven neuroinflammation as a key …

A review of the current mammalian models of Alzheimer's disease and challenges that need to be overcome

NE Mckean, RR Handley, RG Snell - International journal of molecular …, 2021 - mdpi.com
Alzheimer's disease (AD) is one of the looming health crises of the near future. Increasing
lifespans and better medical treatment for other conditions mean that the prevalence of this …

Alzheimer's disease beyond amyloid: Can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery?

K Mullane, M Williams - Biochemical pharmacology, 2020 - Elsevier
Alzheimer's Disease (AD) therapeutics based on the amyloid hypothesis have repeatedly
failed in clinical trials. Together with numerous reports that amyloid is present in brains from …

Animal models of neurodegenerative disease: Recent advances in fly highlight innovative approaches to drug discovery

JA Tello, HE Williams, RM Eppler… - Frontiers in molecular …, 2022 - frontiersin.org
Neurodegenerative diseases represent a formidable challenge to global health. As
advances in other areas of medicine grant healthy living into later decades of life, aging …

The amyloid precursor protein: A converging point in Alzheimer's disease

A Delport, R Hewer - Molecular Neurobiology, 2022 - Springer
The decades of evidence that showcase the role of amyloid precursor protein (APP), and its
fragment amyloidβ (Aβ), in Alzheimer's disease (AD) pathogenesis are irrefutable. However …

What's that (blue) spot on my MRI? Multimodal neuroimaging of the locus coeruleus in neurodegenerative disease

M Kelberman, S Keilholz, D Weinshenker - Frontiers in neuroscience, 2020 - frontiersin.org
The locus coeruleus (LC) has long been underappreciated for its role in the pathophysiology
of Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative …

All roads lead to heterogeneity: the complex involvement of astrocytes and microglia in the pathogenesis of Alzheimer's disease

MK St-Pierre, J VanderZwaag, S Loewen… - Frontiers in Cellular …, 2022 - frontiersin.org
In recent years, glial cells have been acknowledged as key players in the pathogenesis of
Alzheimer's disease (AD), a neurodegenerative condition in which an accumulation of …

Exploring advancements in early detection of Alzheimer's disease with molecular assays and animal models

P Sethi, R Bhaskar, KK Singh, S Gupta, SS Han… - Ageing Research …, 2024 - Elsevier
Alzheimer's Disease (AD) is a challenging neurodegenerative condition, with overwhelming
implications for affected individuals and healthcare systems worldwide. Animal models have …

ADVANCES IN ALZHEIMER'S DISEASE: A MULTIFACETED REVIEW OF POTENTIAL THERAPIES AND DIAGNOSTIC TECHNIQUES FOR EARLY DETECTION

M Sharma, P Pal, SK Gupta - Neurochemistry International, 2024 - Elsevier
Alzheimer's disease (AD) remains one of the most formidable neurological disorders,
affecting millions globally. This review provides a holistic overview of the therapeutic …

Cognitive Deficits and Alzheimer's Disease-Like Pathologies in the Aged Chinese Tree Shrew

H Li, BL Xiang, X Li, C Li, Y Li, Y Miao, GL Ma… - Molecular …, 2024 - Springer
Alzheimer's disease (AD) is the most common chronic progressive neurodegenerative
disease in the elderly. It has an increasing prevalence and a growing health burden. One of …