lncRNA-microRNA axis in cancer drug resistance: particular focus on signaling pathways
Cancer drug resistance remains a formidable challenge in modern oncology, necessitating
innovative therapeutic strategies. The convergence of intricate regulatory networks involving …
innovative therapeutic strategies. The convergence of intricate regulatory networks involving …
Cancer stem cell biomarkers and related signalling pathways
Z Wang, R Li, G Yang, Y Wang - Journal of Drug Targeting, 2024 - Taylor & Francis
Cancer stem cells (CSCs) represent a distinct subset of neoplastic cells characterised by
their heightened capacity for tumorigenesis. These cells are implicated in the facilitation of …
their heightened capacity for tumorigenesis. These cells are implicated in the facilitation of …
The Role of TAMs in the Regulation of Tumor Cell Resistance to Chemotherapy
R McWhorter, B Bonavida - Critical Reviews™ in Oncogenesis, 2024 - dl.begellhouse.com
Tumor-associated macrophages (TAMs) are the predominant cell infiltrate in the
immunosuppressive tumor microenvironment (TME). TAMs are central to fostering pro …
immunosuppressive tumor microenvironment (TME). TAMs are central to fostering pro …
Ratiometric Near-Infrared Fluorescent Probe Monitors Ferroptosis in HCC Cells by Imaging HClO in Mitochondria
B Zhao, X Xu, X Wen, Q Liu, C Dong, Q Yang… - Analytical …, 2024 - ACS Publications
Hypochlorous acid (HClO) is a typical endogenous ROS produced mainly in mitochondria,
and it has strong oxidative properties. Abnormal HClO levels lead to mitochondrial …
and it has strong oxidative properties. Abnormal HClO levels lead to mitochondrial …
[HTML][HTML] Targeting of human cancer stem cells predicts efficacy and toxicity of FDA-approved oncology drugs
K Vojnits, Z Feng, P Johnson, D Porras, E Manocha… - Cancer Letters, 2024 - Elsevier
Cancer remains the leading cause of death worldwide with approved oncology drugs
continuing to have heterogenous patient responses and accompanied adverse effects (AEs) …
continuing to have heterogenous patient responses and accompanied adverse effects (AEs) …
Insights into the role of connexins and specialized intercellular communication pathways in breast cancer: Mechanisms and applications
MRC Mateos, P Carpintero-Fernández… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Gap junctions, membrane-based channels comprised of connexin proteins (Cxs), facilitate
direct communication among neighbouring cells and between cells and the extracellular …
direct communication among neighbouring cells and between cells and the extracellular …
Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics
Recent advances have brought forth the complex interplay between tumor cell plasticity and
its consequential impact on drug resistance and tumor recurrence, both of which are critical …
its consequential impact on drug resistance and tumor recurrence, both of which are critical …
ALDH and cancer stem cells: Pathways, challenges, and future directions in targeted therapy
Human ALDH comprise 19 subfamilies in which ALDH1A1, ALDH1A3, ALDH3A1,
ALDH5A1, ALDH7A1, and ALDH18A1 are implicated in CSC. Studies have shown that …
ALDH5A1, ALDH7A1, and ALDH18A1 are implicated in CSC. Studies have shown that …
[HTML][HTML] Effective therapy of advanced breast cancer through synergistic anticancer by paclitaxel and P-glycoprotein inhibitor
S Zhu, C Sun, Z Cai, Y Li, W Liu, Y Luan, C Wang - Materials Today Bio, 2024 - Elsevier
Multi-drug resistance (MDR) in advanced breast cancer (ABC) is triggered by the high
expression of P-glycoprotein (P-gp), which reduces intracellular concentration of anti-tumor …
expression of P-glycoprotein (P-gp), which reduces intracellular concentration of anti-tumor …
Kinase Inhibitors and Kinase-Targeted Cancer Therapies: Recent Advances and Future Perspectives
J Li, C Gong, H Zhou, J Liu, X Xia, W Ha… - International Journal of …, 2024 - mdpi.com
Over 120 small-molecule kinase inhibitors (SMKIs) have been approved worldwide for
treating various diseases, with nearly 70 FDA approvals specifically for cancer treatment …
treating various diseases, with nearly 70 FDA approvals specifically for cancer treatment …