Different studies have led to our present knowledge of the membrane receptors responsible
for mediating the responses to the endogenous catecholamines. These receptors were …

The a, ARs are important mediators of sympathetic nervous system responses, particularly
those involved in cardiovascular homeostasis, such as arteriolar smooth muscle constriction …

There is considerable interest in the regulation of the extracellular compartment of the
transmitter serotonin (5-hydroxytryptamine, 5-HT) in the midbrain raphe nuclei because it …

Molecular cloning studies have revealed the existence of three subtypes of alpha 1-
adrenergic receptors. However, the link between any individual subtype and its functional …

alpha 1-Adrenergic agonists induce a hypertrophic phenotype in cultured neonatal rat
ventricular myocytes. Quantifiable markers of this phenotype include stimulation of …

alpha 1-Adrenergic receptors (alpha 1ARs) are virtually ubiquitous in human tissues and
mediate important physiological functions as diverse as smooth muscle contraction …

Two α 1-adrenoceptor subtypes (α 1A and α 1B) have been detected in various tissues by
pharmacological techniques, and three distinct cDNAs encoding α 1-adrenoceptor subtypes …

The potencies and intrinsic activities of agonists in activating cloned alpha 1-adrenergic
receptor (AR) subtypes were compared. The hamster alpha 1B-, bovine alpha 1C-, or rat …

We have cloned cDNAs encoding three human alpha-i adren-ergic receptor(AR) subtypes
and characterized pharmacological properties of the expressed receptor protein. A number …

alpha 1-Adrenergic receptors (ARs) are members of the G protein-coupled receptor
superfamily. alpha 1-AR subtypes mediate the effects of the sympathetic nervous system …