Neoadjuvant radioimmunotherapy in pancreatic cancer enhances effector T cell infiltration and shortens their distances to tumor cells

J Wang, J Gai, T Zhang, N Niu, H Qi, DL Thomas… - Science …, 2024 - science.org
Radiotherapy is hypothesized to have an immune-modulating effect on the tumor
microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) to sensitize it to anti …

Macrophage-coated tumor cluster aggravates hepatoma invasion and immunotherapy resistance via generating local immune deprivation

J Ning, Y Ye, H Shen, R Zhang, H Li, T Song… - Cell Reports …, 2024 - cell.com
Immune checkpoint inhibitors (ICIs) represent a promising treatment for hepatocellular
carcinoma (HCC) due to their capacity for abundant lymphocyte infiltration. However, some …

Efficacy and biomarker analysis of second‐line nab‐paclitaxel plus sintilimab in patients with advanced biliary tract cancer

X Li, N Zhou, Y Yang, Z Lu, H Gou - Cancer Science, 2024 - Wiley Online Library
Biliary tract cancer (BTC) is a highly aggressive malignancy with limited second‐line
therapy. We conducted this phase 2 trial to evaluate the efficacy and safety of second‐line …

Characteristics of mast cell infiltration in lung adenocarcinoma and its impact on prognosis

Z Qiu, G Pang, X Xu, J Lin, P Wang - Discover Oncology, 2024 - Springer
Background The role of mast cells in malignancies remains unclear, and there is no clear
correlation between mast cells and tumor microvessels, tumor growth, or lung …