Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly
ZS Galis, JJ Khatri - Circulation research, 2002 - Am Heart Assoc
Vascular remodeling, defined as any enduring change in the size and/or composition of an
adult blood vessel, allows adaptation and repair. On the other hand, inappropriate …
adult blood vessel, allows adaptation and repair. On the other hand, inappropriate …
Atherothrombosis and high-risk plaque: part I: evolving concepts
Atherothrombosis is a complex disease in which cholesterol deposition, inflammation, and
thrombus formation play a major role. Rupture of high-risk, vulnerable plaques is …
thrombus formation play a major role. Rupture of high-risk, vulnerable plaques is …
Which white blood cell subtypes predict increased cardiovascular risk?
BD Horne, JL Anderson, JM John, A Weaver… - Journal of the american …, 2005 - jacc.org
Objectives: We sought to determine the predictive ability of total white blood cell (WBC)
count and its subtypes for risk of death or myocardial infarction (MI). Background: An …
count and its subtypes for risk of death or myocardial infarction (MI). Background: An …
Matrix metalloproteinases: a review of their structure and role in acute coronary syndrome
CB Jones, DC Sane, DM Herrington - Cardiovascular research, 2003 - academic.oup.com
Objective: To summarize the structure, function, and regulation of matrix metalloproteinases
(MMPs) and to review the literature to date on their potential role in the pathogenesis of …
(MMPs) and to review the literature to date on their potential role in the pathogenesis of …
Molecular, endocrine, and genetic mechanisms of arterial calcification
TM Doherty, LA Fitzpatrick, D Inoue, JH Qiao… - Endocrine …, 2004 - academic.oup.com
Pathologists have recognized arterial calcification for over a century. Recent years have
witnessed a strong resurgence of interest in atherosclerotic plaque calcification because it …
witnessed a strong resurgence of interest in atherosclerotic plaque calcification because it …
Involvement of fatty acids and their metabolites in the development of inflammation in atherosclerosis
S Kotlyarov, A Kotlyarova - International journal of molecular sciences, 2022 - mdpi.com
Despite all the advances of modern medicine, atherosclerosis continues to be one of the
most important medical and social problems. Atherosclerosis is the cause of several …
most important medical and social problems. Atherosclerosis is the cause of several …
Plaque rupture in humans and mice
SM Schwartz, ZS Galis, ME Rosenfeld… - … , and vascular biology, 2007 - Am Heart Assoc
Despite the many studies of murine atherosclerosis, we do not yet know the relevance of the
natural history of this model to the final events precipitated by plaque disruption of human …
natural history of this model to the final events precipitated by plaque disruption of human …
Metabolic syndrome modifies the cardiovascular risk associated with angiographic coronary artery disease in women: a report from the Women's Ischemia Syndrome …
OC Marroquin, KE Kip, DE Kelley, BD Johnson… - Circulation, 2004 - Am Heart Assoc
Background—The metabolic syndrome, which is characterized by a constellation of fasting
hyperglycemia, hypertriglyceridemia, low HDL cholesterol, hypertension, and/or abdominal …
hyperglycemia, hypertriglyceridemia, low HDL cholesterol, hypertension, and/or abdominal …
Increased expression of membrane type 3-matrix metalloproteinase in human atherosclerotic plaque: role of activated macrophages and inflammatory cytokines
H Uzui, A Harpf, M Liu, TM Doherty, A Shukla… - Circulation, 2002 - Am Heart Assoc
Background—Matrix metalloproteinases (MMPs) are thought to play a prominent role in
atherogenesis and destabilization of plaque. Pericellularly localized membrane-type (MT) …
atherogenesis and destabilization of plaque. Pericellularly localized membrane-type (MT) …
Toll-like receptor 2, hyaluronan, and neutrophils play a key role in plaque erosion: the OPTICO–ACS study
Background and aims In one-third of patients with acute coronary syndrome (ACS),
thrombosis occurs despite an intact fibrous cap (IFC)(IFC–ACS,'plaque erosion'). Recent …
thrombosis occurs despite an intact fibrous cap (IFC)(IFC–ACS,'plaque erosion'). Recent …