Chimeric antigen receptor T cells: a race to revolutionize cancer therapy

M Subklewe, M von Bergwelt-Baildon… - Transfusion Medicine …, 2019 - karger.com
For years, cancer treatment was dominated by chemotherapy, radiation therapy, and stem
cell transplantation. New insights into genetic characteristics of leukemic cells have initiated …

[HTML][HTML] Chimeric antigen receptor-T-cell therapy for B-cell hematological malignancies: an update of the pivotal clinical trial data

G Roex, T Feys, Y Beguin, T Kerre, X Poiré, P Lewalle… - Pharmaceutics, 2020 - mdpi.com
Chimeric antigen receptor (CAR)-T-cell therapy is an innovative form of adoptive cell therapy
that has revolutionized the treatment of certain hematological malignancies, including B-cell …

In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation

PD Kottaridis, DW Milligan, R Chopra… - Blood, The Journal …, 2000 - ashpublications.org
A novel nonmyeloablative conditioning regimen was investigated in 44 patients with
hematologic malignancies. The median patient age was 41 years. Many of the patients had …

Chemoresistant or aggressive lymphoma predicts for a poor outcome following reduced-intensity allogeneic progenitor cell transplantation: an analysis from the …

SP Robinson, AH Goldstone… - Blood, The Journal …, 2002 - ashpublications.org
We report the outcome of reduced-intensity allogeneic progenitor cell transplantation
(alloPCT) for 188 patients with lymphoma from the Working Party Lymphoma of the …

[PDF][PDF] Increasing mixed chimerism is an important prognostic factor for unfavorable outcome in children with acute lymphoblastic leukemia after allogeneic stem-cell …

P Bader, H Kreyenberg, W Hoelle… - Journal of clinical …, 2004 - researchgate.net
Purpose We recently reported that children with acute leukemias who show increasing
mixed chimerism (MC) after allogeneic stem-cell transplantation have a significantly …

[PDF][PDF] Prospective trial of chemotherapy and donor leukocyte infusions for relapse of advanced myeloid malignancies after allogeneic stem-cell transplantation

JE Levine, T Braun, SL Penza, P Beatty… - Journal of Clinical …, 2002 - academia.edu
Purpose: Patients with advanced myeloid malig-nancies who experience relapse after
allogeneic bone marrow transplantation (BMT) have a poor prognosis. Long-term survival …

Second allogeneic transplantation for relapse of malignant disease: retrospective analysis of outcome and predictive factors by the EBMT

T Ruutu, LC De Wreede, A Van Biezen… - Bone marrow …, 2015 - nature.com
In patients treated with allogeneic stem cell transplantation (SCT) for malignant disease who
suffer from a relapse after the transplantation, the role of second allogeneic SCT is often …

Graft-versus-host disease and outcome in HLA-identical sibling transplantations for chronic myeloid leukemia

A Gratwohl, R Brand, J Apperley… - Blood, The Journal …, 2002 - ashpublications.org
Graft-versus-host disease in its acute (aGvHD) or chronic form (cGvHD) remains the most
important posttransplantation factor influencing outcome after allogeneic hematopoietic stem …

Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation

E Rettinger, AM Willasch, H Kreyenberg… - Blood, The Journal …, 2011 - ashpublications.org
Previous studies have shown that children with acute myeloid leukemia (AML) who
developed mixed chimerism (MC) were at high risk for relapse after allogeneic stem-cell …

Th2 and Tc2 cells in the regulation of GVHD, GVL, and graft rejection: considerations for the allogeneic transplantation therapy of leukemia and lymphoma

DH Fowler, RE Gress - Leukemia & lymphoma, 2000 - Taylor & Francis
Allogeneic stem cell transplantation (SCT) represents a curative treatment option for patients
with leukemia and lymphoma. T lymphocytes contained in the allograft mediate a graft …