[HTML][HTML] Targeting cancer stem cell pathways for cancer therapy
L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
[HTML][HTML] Lung cancers: molecular characterization, clonal heterogeneity and evolution, and cancer stem cells
U Testa, G Castelli, E Pelosi - Cancers, 2018 - mdpi.com
Lung cancer causes the largest number of cancer-related deaths in the world. Most (85%) of
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …
lung cancers are classified as non-small-cell lung cancer (NSCLC) and small-cell lung …
[HTML][HTML] Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy
T Yong, X Zhang, N Bie, H Zhang, X Zhang, F Li… - Nature …, 2019 - nature.com
Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major
challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell …
challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell …
Epithelial–mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis
T Chen, Y You, H Jiang, ZZ Wang - Journal of cellular …, 2017 - Wiley Online Library
The lineage transition between epithelium and mesenchyme is a process known as
epithelial–mesenchymal transition (EMT), by which polarized epithelial cells lose their …
epithelial–mesenchymal transition (EMT), by which polarized epithelial cells lose their …
[HTML][HTML] ABC transporters in cancer stem cells: beyond chemoresistance
RR Begicevic, M Falasca - International journal of molecular sciences, 2017 - mdpi.com
The efficacy of chemotherapy is one of the main challenges in cancer treatment and one of
the major obstacles to overcome in achieving lasting remission and a definitive cure in …
the major obstacles to overcome in achieving lasting remission and a definitive cure in …
Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas
Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …
Tackling the cancer stem cells—what challenges do they pose?
DR Pattabiraman, RA Weinberg - Nature reviews Drug discovery, 2014 - nature.com
Since their identification in 1994, cancer stem cells (CSCs) have been objects of intensive
study. Their properties and mechanisms of formation have become a major focus of current …
study. Their properties and mechanisms of formation have become a major focus of current …
[HTML][HTML] Cancer stem cell surface markers on normal stem cells
WT Kim, CJ Ryu - BMB reports, 2017 - ncbi.nlm.nih.gov
The cancer stem cell (CSC) hypothesis has captured the attention of many scientists. It is
believed that elimination of CSCs could possibly eradicate the whole cancer. CSC surface …
believed that elimination of CSCs could possibly eradicate the whole cancer. CSC surface …
[HTML][HTML] Understanding and targeting cancer stem cells: therapeutic implications and challenges
K Chen, Y Huang, J Chen - Acta Pharmacologica Sinica, 2013 - nature.com
Cancer stem cells (CSCs) have been identified as rare cell populations in many cancers,
including leukemia and solid tumors. Accumulating evidence has suggested that CSCs are …
including leukemia and solid tumors. Accumulating evidence has suggested that CSCs are …
[HTML][HTML] Cancer stem cells—key players in tumor relapse
M Marzagalli, F Fontana, M Raimondi, P Limonta - Cancers, 2021 - mdpi.com
Simple Summary Cancer is one of the hardest pathologies to fight, being one of the main
causes of death worldwide despite the constant development of novel therapeutic strategies …
causes of death worldwide despite the constant development of novel therapeutic strategies …