Hepatoprotective effects of natural drugs: Current trends, scope, relevance and future perspectives

S Datta, D Aggarwal, N Sehrawat, M Yadav, V Sharma… - Phytomedicine, 2023 - Elsevier
Background: The liver is a well-known player in the metabolism and removal of drugs. Drug
metabolizing enzymes in the liver detoxify drugs and xenobiotics, ultimately leading to the …

The potential effects of quercetin-loaded nanoliposomes on amoxicillin/clavulanate-induced hepatic damage: targeting the Sirt1/Nrf2/Nf-κB signaling pathway and …

MM Abd El-Emam, M Mostafa, AA Farag, HS Youssef… - Antioxidants, 2023 - mdpi.com
Amoxicillin/clavulanate (Co-Amox), a commonly used antibiotic for the treatment of bacterial
infections, has been associated with drug-induced liver damage. Quercetin (QR), a naturally …

Sulforaphane prevents LPS-induced inflammation by regulating the Nrf2-mediated autophagy pathway in goat mammary epithelial cells and a mouse model of …

D Shao, W Shen, Y Miao, Z Gao, M Pan, Q Wei… - Journal of Animal …, 2023 - Springer
Background Mastitis not only deteriorates the composition or quality of milk, but also
damages the health and productivity of dairy goats. Sulforaphane (SFN) is a phytochemical …

The role of Nrf2 signaling pathways in nerve damage repair

A Abdolmaleki, A Karimian, SM Khoshnazar… - Toxicology …, 2024 - academic.oup.com
The protein, Nuclear factor-E2-related factor 2 (Nrf2), is a transitory protein that acts as a
transcription factor and is involved in the regulation of many cytoprotective genes linked to …

Avicularin alleviates acute liver failure by regulation of the TLR4/MyD88/NF‐κB and Nrf2/HO‐1/GPX4 pathways to reduce inflammation and ferroptosis

P Shi, W Zhu, J Fu, A Liang, T Zheng… - Journal of Cellular …, 2023 - Wiley Online Library
Acute liver failure (ALF) is an inflammation‐mediated hepatocyte death process associated
with ferroptosis. Avicularin (AL), a Chinese herbal medicine, exerts anti‐inflammatory and …

Dihydroquercetin supplementation improved hepatic lipid dysmetabolism mediated by gut microbiota in high-fat diet (HFD)-fed mice

M Wang, H Han, F Wan, R Zhong, YJ Do, SI Oh, X Lu… - Nutrients, 2022 - mdpi.com
Dihydroquercetin (DHQ) is a natural flavonoid with multiple bioactivities, including
hepatoprotective effects. This study aimed to investigate whether DHQ improved lipid …

[HTML][HTML] NUP85 alleviates lipid metabolism and inflammation by regulating PI3K/AKT signaling pathway in nonalcoholic fatty liver disease

Y Wu, Q Yan, S Yue, L Pan, D Yang, L Tao… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is one of the common causes of chronic liver
disease in the world. The problem of NAFLD had become increasingly prominent. However …

Gualou-Xiebai herb pair and its active ingredients act against atherosclerosis by suppressing VSMC-derived foam cell formation via regulating P2RY12-mediated …

Y Bao, L Zhu, Y Wang, J Liu, Z Liu, Z Li, A Zhou, H Wu - Phytomedicine, 2024 - Elsevier
Background Atherosclerosis (AS) is a chronic disease characterized by lipid accumulation in
the aortic wall and the formation of foam cells overloaded with large lipids inclusions …

[HTML][HTML] Lactobacillus plantarum J26 alleviates alcohol-induced oxidative liver injury by regulating the Nrf2 signaling pathway

H Li, S Cheng, Y Wang, Y Sun, J Zhang, M Sun… - Food Science and …, 2024 - Elsevier
Oxidative stress is one of the main ways to cause alcohol-induced liver injury, and alcoholic
liver disease (ALD) has been a common health problem worldwide. Lactic acid bacteria …

[HTML][HTML] Multi-therapeutic potential of flavonoids as an essential component in nutraceuticals for the treatment and management of human diseases

SIR Okoduwa, I Abdulwaliyu, BE Igiri, SO Arekemase… - Phytomedicine Plus, 2024 - Elsevier
Background Diseases are one of the factors affecting human and national development in
all its ramifications. Some of the diseases that affect humans are usually difficult to manage …