Both activating and inactivating mutations in catenin β1 (ctnnb1), which encodes β‐catenin,
have been implicated in liver tumorigenesis in humans and mice, although the underlying …

Simple Summary Liver cancer is one of the most difficult solid tumors to treat and is
responsible for one-third of cancer-related deaths worldwide. In particular, the quest for …

Clinical trials completed in the last two decades have contributed significantly to the
improved overall survival of children with cancer. In spite of these advancements, disease …

The survival rate for patients with metastatic hepatoblastoma (HB) is steadily increased in
the last thirty years from 27% to 79%. These achievements result from accurate risk …

Organ-like microenviroment and 3-dimensional (3D) cell culture conformations have been
suggested as promising approaches to mimic in a micro-scale a whole organ cellular …

In this study, a novel mouse model of hepatocellular carcinoma (HCC) was established by
simultaneously knocking out Pten and p53 suppressor genes and overexpressing c-Met …

The Wnt/β-catenin signaling pathway plays a crucial role in various physiological processes,
encompassing development, tissue homeostasis, and cell proliferation. Under normal …

ABSTRACT IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a ubiquitously
expressed scaffolding protein that is overexpressed in a number of cancers, including liver …

Hepatocellular carcinoma (HCC) is by far the most common histological subtype of primary
liver cancer. HCC often originates from chronic liver injuries and inflammation, subsequently …

Simultaneous mutations in CTNNB1 and activation of c-MET occur in 9%–12.5% of patients
with hepatocellular carcinoma (HCC). Coexpression of c-MET-V5 and mutant β-catenin-Myc …