Obesity: epidemiology, pathophysiology, and therapeutics

X Lin, H Li - Frontiers in endocrinology, 2021 - frontiersin.org
Obesity is a complex multifactorial disease that accumulated excess body fat leads to
negative effects on health. Obesity continues to accelerate resulting in an unprecedented …

Hallmarks of health

C López-Otín, G Kroemer - Cell, 2021 - cell.com
Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

The gut microbiota in obesity and weight management: microbes as friends or foe?

M Van Hul, PD Cani - Nature Reviews Endocrinology, 2023 - nature.com
Obesity is caused by a long-term difference between energy intake and expenditure—an
imbalance that is seemingly easily restored by increasing exercise and reducing caloric …

Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled …

V Mocanu, Z Zhang, EC Deehan, DH Kao, N Hotte… - Nature Medicine, 2021 - nature.com
Fecal microbial transplantation (FMT) from lean donors to patients with obesity has been
associated with metabolic benefits, yet results so far have been inconsistent. In this study …

Gut microbiome, big data and machine learning to promote precision medicine for cancer

G Cammarota, G Ianiro, A Ahern, C Carbone… - Nature reviews …, 2020 - nature.com
The gut microbiome has been implicated in cancer in several ways, as specific microbial
signatures are known to promote cancer development and influence safety, tolerability and …

Antimicrobial resistance and recent alternatives to antibiotics for the control of bacterial pathogens with an emphasis on foodborne pathogens

YA Helmy, K Taha-Abdelaziz, HAEH Hawwas, S Ghosh… - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance (AMR) is one of the most important global public health problems.
The imprudent use of antibiotics in humans and animals has resulted in the emergence of …

Dysbiotic gut bacteria in obesity: an overview of the metabolic mechanisms and therapeutic perspectives of next-generation probiotics

J Breton, M Galmiche, P Déchelotte - Microorganisms, 2022 - mdpi.com
Obesity, a worldwide health concern with a constantly rising prevalence, is a multifactorial
chronic disease associated with a wide range of physiological disruptions, including energy …

Novel noninvasive approaches to the treatment of obesity: from pharmacotherapy to gene therapy

AM Angelidi, MJ Belanger, A Kokkinos… - Endocrine …, 2022 - academic.oup.com
Recent insights into the pathophysiologic underlying mechanisms of obesity have led to the
discovery of several promising drug targets and novel therapeutic strategies to address the …

Human microbiome and metabolic health: An overview of systematic reviews

N Michels, S Zouiouich, B Vanderbauwhede… - Obesity …, 2022 - Wiley Online Library
To summarize the microbiome's role in metabolic disorders (insulin resistance,
hyperglycemia, type 2 diabetes, obesity, hyperlipidemia, hypertension, nonalcoholic fatty …

A Smartphone Optical Device for Point-of-Care Testing of Glucose and Cholesterol Using Ag NPs/UiO-66-NH2-Based Ratiometric Fluorescent Probe

L Guo, S Chen, YL Yu, JH Wang - Analytical Chemistry, 2021 - ACS Publications
Point-of-care testing (POCT) with the advantages of simplicity, rapidity, portability, and low-
cost is of great importance to improve healthcare, especially in resource-limited settings and …