Developing greener synthesis processes is an inescapable necessity to transform the
industrial landscape, mainly in the pharmaceutical sector, into a long-term, sustainable …

Since the last century, peptides have gained wide acceptance as drugs, with almost 100
already in the market and a large number in the pipeline. In this context, peptide synthesis …

Solid-phase peptide synthesis (SPPS) is generally the method of choice for the chemical
synthesis of peptides, allowing routine synthesis of virtually any type of peptide sequence …

Small molecule therapeutics represent the majority of the FDA-approved drugs. Yet, many
attractive targets are poorly tractable by small molecules, generating a need for new …

Peptide therapeutics represents a significant and growing area for manufacturing
companies utilizing both chemical and recombinant methods. Approvals for orally …

Artificial solid-state nanochannels have garnered considerable attention as promising
nanofluidic tools for ion/molecular detection, DNA sequencing, and biomimicry. Recently …

N-Substituted glycines (peptoids) are a class of peptidomimetic molecules used as materials
for health, environmental, and drug delivery applications. Automated solid-phase synthesis …

Two new recyclable silicon-based hydrophobic tags were developed for installing them at
the C-terminal of peptides to increase the solubility in organic solvents and the reactivity of …

Coupling or condensation reagents are compounds that can be used to promote the direct
condensation of carboxylic acids with amines or alcohols to furnish amide or ester bond …

Plecanatide is an oral guanylate cyclase-C agonist for the treatment of gastrointestinal
disorders. The large-scale supply of plecanatide is restrained primarily by its industrial …