Abstract cGMP controls many cellular functions ranging from growth, viability, and
differentiation to contractility, secretion, and ion transport. The mammalian genome encodes …

Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of
disorders characterised by photoreceptor degeneration or dysfunction. These disorders …

The~ 100 MB genome of C. elegans codes for~ 20,000 protein-coding genes many of which
are required for the function of the nervous system, composed of 302 neurons in the adult …

Progressive cone and cone-rod dystrophies are a clinically and genetically heterogeneous
group of inherited retinal diseases characterised by cone photoreceptor degeneration …

Seeing begins in the photoreceptors, where light is absorbed and signaled to the nervous
system. Throughout the animal kingdom, photoreceptors are diverse in design and purpose …

In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter
release and in triggering alterations in neuronal function. Calmodulin has been widely …

Inherited retinal diseases (IRD) are a leading cause of blindness in the working age
population and children. The scope of this review is to familiarise clinicians and scientists …

Nitric oxide, bicarbonate, natriuretic peptides (ANP, BNP and CNP), guanylins, uroguanylins
and guanylyl cyclase activating proteins (GCAPs) activate a family of enzymes variously …

▪ Abstract Cyclic nucleotide–activated ion channels play a fundamental role in a variety of
physiological processes. By opening in response to intracellular cyclic nucleotides, they …

The cone and cone–rod dystrophies form part of a heterogeneous group of retinal disorders
that are an important cause of visual impairment in children and adults. There have been …