In the healthy endometrium, progesterone and estrogen signaling coordinate in a tightly
regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo …

Nuclear receptors (NRs) are a family of transcription factors that regulate numerous
physiological processes such as metabolism, reproduction, inflammation, as well as the …

The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory
factor (TRF) that controls many distinct gene networks, each uniquely determined by …

Owing to the development of multiple novel therapies, there has been major progress in the
treatment of advanced prostate cancer over the last two decades; however, the disease …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

Summary Estrogen receptor (ER/ESR1) is a transcription factor critical for development,
reproduction, metabolism, and cancer. ER function hinges on its ability to recruit primary and …

Glucocorticoids (GCs) are a class of steroid hormones that regulate key physiological
processes such as metabolism, immune function, and stress responses. The effects of GCs …

Although auxin and brassinosteroid (BR) synergistically control various plant responses, the
molecular mechanism underlying the auxin–BR crosstalk is not well understood. We …

During postembryonic life, hormones, including ecdysteroids, juvenile hormones, insulin-like
peptides, and activin/TGFβ ligands act to transform the larval nervous system into an adult …

The estrogen receptor alpha (ERα) is a steroid receptor that is pivotal in the initiation and
progression of most breast cancers. ERα regulates gene transcription through recruitment of …