The gastrointestinal tract has recently come to the forefront of multiple research fields. It is
now recognized as a major source of signals modulating food intake, insulin secretion and …

Extracellular matrix (ECM) plays a central and dynamic role in the creation of tumor
microenvironment. Herein we discuss the emerging biophysical and biochemical aspects of …

The successful transplantation of stem cells has the potential to transform regenerative
medicine approaches and open promising avenues to repair, replace, and regenerate …

The adult CNS contains an abundant population of oligodendrocyte precursor cells (NG2+
cells) that generate oligodendrocytes and repair myelin, but how these ubiquitous …

Many tissues and organ systems in metazoans have the intrinsic capacity to regenerate,
which is driven and maintained largely by tissue-resident somatic stem cell populations …

Aging is a natural process of organismal decay that underpins the development of myriad
diseases and disorders. Extensive efforts have been made to understand the biology of …

Commensal microbes colonize the gut epithelia of virtually all animals and provide several
benefits to their hosts. Changes in commensal populations can lead to dysbiosis, which is …

Interactions between commensals and the host impact the metabolic and immune status of
metazoans. Their deregulation is associated with age-related pathologies like chronic …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is ubiquitously expressed in most eukaryotic
cells and functions to induce a broad range of cellular defenses against exogenous and …

Compartmentalization of the gastrointestinal (GI) tract of metazoans is critical for health. GI
compartments contain specific microbiota, and microbiota dysbiosis is associated with …