The role of m6A RNA methylation in cancer metabolism

Y An, H Duan - Molecular cancer, 2022 - Springer
Metabolic reprogramming is one of the main characteristics of malignant tumors, which is
due to the flexible changes of cell metabolism that can meet the needs of cell growth and …

m6A modification: recent advances, anticancer targeted drug discovery and beyond

LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …

Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets

J Yang, J Xu, W Wang, B Zhang, X Yu… - Signal transduction and …, 2023 - nature.com
Over decades, researchers have focused on the epigenetic control of DNA-templated
processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification …

Role of m6A writers, erasers and readers in cancer

Z Fang, W Mei, C Qu, J Lu, L Shang, F Cao… - … Hematology & Oncology, 2022 - Springer
Abstract The N (6)-methyladenosine (m6A) modification is the most pervasive modification of
human RNAs. In recent years, an increasing number of studies have suggested that m6A …

N6-methyladenosine methyltransferases: functions, regulation, and clinical potential

W Huang, TQ Chen, K Fang, ZC Zeng, H Ye… - Journal of Hematology & …, 2021 - Springer
Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …

METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer

X Chen, MU Xu, X Xu, K Zeng, X Liu, B Pan, C Li… - Molecular cancer, 2020 - Springer
Background Colorectal cancer (CRC) is one of the leading causes of tumor-related death
worldwide, and its main cause of death is distant metastasis. Methyltransferase-like 14 …

[HTML][HTML] The m6A readers YTHDF1 and YTHDF3 aberrations associated with metastasis and predict poor prognosis in breast cancer patients

R Anita, A Paramasivam, JV Priyadharsini… - American journal of …, 2020 - ncbi.nlm.nih.gov
Abstract N6-Methyladenosine (m6A) is the most common RNA modification in eukaryotic
mRNAs and growing evidence suggests the crucial roles of m6A and its regulators in human …

[HTML][HTML] Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR

H Liu, T Lan, H Li, L Xu, X Chen, H Liao, X Chen… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: circular RNAs (circRNAs) have been demonstrated to play a crucial role in cancer
progression. KIAA1429, a key component of the m6A methyltransferase complex, has …

The biological function of m6A demethylase ALKBH5 and its role in human disease

J Wang, J Wang, Q Gu, Y Ma, Y Yang, J Zhu… - Cancer cell …, 2020 - Springer
Abstract Human AlkB homolog H5 (ALKBH5) is a primary m6A demethylase, which is
dysregulated and acts as a biological and pharmacological role in human cancers or non …

A review on the role of cyclin dependent kinases in cancers

S Ghafouri-Fard, T Khoshbakht, BM Hussen… - Cancer Cell …, 2022 - Springer
The Cyclin-dependent kinase (CDK) class of serine/threonine kinases has crucial roles in
the regulation of cell cycle transition and is mainly involved in the pathogenesis of cancers …