Local immune recognition of trophoblast in early human pregnancy: controversies and questions

A Moffett, N Shreeve - Nature Reviews Immunology, 2023 - nature.com
The role of the maternal immune system in reproductive success in humans remains
controversial. Here we focus on the events that occur in the maternal decidua during the first …

COVID-19 and pregnancy: clinical outcomes; mechanisms, and vaccine efficacy

D Kumar, S Verma, IU Mysorekar - Translational Research, 2023 - Elsevier
As the COVID-19 pandemic continues into its third year, emerging data indicates increased
risks associated with SARS-CoV-2 infection during pregnancy, including pre-eclampsia …

[HTML][HTML] Spatial multiomics map of trophoblast development in early pregnancy

A Arutyunyan, K Roberts, K Troulé, FCK Wong… - Nature, 2023 - nature.com
The relationship between the human placenta—the extraembryonic organ made by the
fetus, and the decidua—the mucosal layer of the uterus, is essential to nurture and protect …

[HTML][HTML] 3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages

RM Karvas, JE Zemke, SS Ali, E Upton, E Sane… - Cell Stem Cell, 2023 - cell.com
Naive human pluripotent stem cells have the remarkable ability to self-organize into
blastocyst-like structures (" blastoids") that model lineage segregation in the pre …

A placental model of SARS-CoV-2 infection reveals ACE2-dependent susceptibility and differentiation impairment in syncytiotrophoblasts

J Chen, JA Neil, JP Tan, R Rudraraju, M Mohenska… - Nature Cell …, 2023 - nature.com
SARS-CoV-2 infection causes COVID-19. Several clinical reports have linked COVID-19
during pregnancy to negative birth outcomes and placentitis. However, the …

Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy

M Wang, Y Liu, R Sun, F Liu, J Li, L Yan, J Zhang… - Nature Genetics, 2024 - nature.com
The human placenta has a vital role in ensuring a successful pregnancy. Despite the
growing body of knowledge about its cellular compositions and functions, there has been …

Zika virus targets human trophoblast stem cells and prevents syncytialization in placental trophoblast organoids

H Wu, XY Huang, MX Sun, Y Wang, HY Zhou… - Nature …, 2023 - nature.com
Zika virus (ZIKV) infection during pregnancy threatens pregnancy and fetal health. However,
the infectivity and pathological effects of ZIKV on placental trophoblast progenitor cells in …

Reprogrammed blastoids contain amnion-like cells but not trophectoderm

C Zhao, AP Reyes, JP Schell, J Weltner, N M. Ortega… - biorxiv, 2021 - biorxiv.org
With the advancement of human stem cell cultures and interest in understanding human
embryogenesis, human blastocyst-like structures, or human blastoids, are being developed …

A comprehensive review of human trophoblast fusion models: recent developments and challenges

X Li, ZH Li, YX Wang, TH Liu - Cell Death Discovery, 2023 - nature.com
As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast
layer contributes to a successful pregnancy by secreting hormones necessary for …

Single-nuclei RNA sequencing (snRNA-seq) uncovers trophoblast cell types and lineages in the mature bovine placenta

KM Davenport, MS Ortega, H Liu… - Proceedings of the …, 2023 - National Acad Sciences
Ruminants have a semi-invasive placenta, which possess highly vascularized placentomes
formed by maternal endometrial caruncles and fetal placental cotyledons and required for …