Abstract Cushing's disease (CD), or pituitary-dependent Cushing's syndrome, is a severe
endocrine disease caused by a corticotroph pituitary tumor and associated with increased …

Selective progesterone receptor modulators (SPRMs) represent a new class of
progesterone receptor ligands. SPRMs exert clinically relevant tissue-selective …

Context: Cushing's syndrome (CS) is a disorder associated with significant morbidity and
mortality due to prolonged exposure to high cortisol concentrations. Objective: Our objective …

Background Emergency contraception can prevent unintended pregnancies, but current
methods are only effective if used as soon as possible after sexual intercourse and before …

The war against cancer traces back to the signature event half-a-century ago when the US
National Cancer Act was signed into law. The cancer crusade costs trillions with …

Triple-negative breast cancer (TNBC) is currently the most malignant subtype of breast
cancers without effective targeted therapies. Mifepristone (MIF), a drug regularly used for …

Uterine leiomyomata are the most common benign tumors of the gynecologic tract impacting
up to 80% of women by 50 years of age. It is well established that these tumors are the …

Objective This guideline reviews the evidence relating to the provision of first-trimester
medical induced abortion, including patient eligibility, counselling, and consent; evidence …

Induced abortion is still a major health problem in the world and the most frequently
performed intervention in obstetrics and gynecology with an estimated total of 46 million …

Context Mifepristone (RU 486) blocks the action of cortisol by binding to the glucocorticoid
receptor and, therefore, is of potential therapeutic value in Cushing's syndrome. However …