Mesenchymal stem cells isolated from adipose and other tissues: basic biological properties and clinical applications

H Orbay, M Tobita, H Mizuno - Stem cells international, 2012 - Wiley Online Library
Mesenchymal stem cells (MSCs) are adult stem cells that were initially isolated from bone
marrow. However, subsequent research has shown that other adult tissues also contain …

Mesenchymal stem cells: potential in treatment of neurodegenerative diseases

T Tanna, V Sachan - Current stem cell research & therapy, 2014 - ingentaconnect.com
Mesenchymal Stem Cells or Marrow Stromal Cells (MSCs) have long been viewed as a
potent tool for regenerative cell therapy. MSCs are easily accessible from both healthy donor …

[HTML][HTML] Human placenta-derived cells (PDA-001) for the treatment of adults with multiple sclerosis: a randomized, placebo-controlled, multiple-dose study

FD Lublin, JD Bowen, J Huddlestone… - Multiple sclerosis and …, 2014 - Elsevier
Background Infusion of PDA-001, a preparation of mesenchymal-like cells derived from full-
term human placenta, is a new approach in the treatment of patients with multiple sclerosis …

Prostaglandin E2 indicates therapeutic efficacy of mesenchymal stem cells in experimental traumatic brain injury

DJ Kota, KS Prabhakara, N Toledano-Furman… - Stem …, 2017 - academic.oup.com
Traumatic brain injury (TBI) is soon predicted to become the third leading cause of death
and disability worldwide. After the primary injury, a complex set of secondary injuries …

Adipose-derived mesenchymal stem cells improve glucose homeostasis in high-fat diet-induced obese mice

M Cao, Q Pan, H Dong, X Yuan, Y Li, Z Sun… - Stem cell research & …, 2015 - Springer
Introduction Effective therapies for obesity and diabetes are still lacking. The aim of this
study was to evaluate whether a single intravenous infusion of syngeneic adipose-derived …

Human intracerebroventricular (ICV) injection of autologous, non-engineered, adipose-derived stromal vascular fraction (ADSVF) for neurodegenerative disorders …

C Duma, O Kopyov, A Kopyov, M Berman… - Molecular Biology …, 2019 - Springer
We have chosen to test the safety of human intracerebroventricular (ICV) brain injections of
autologous non-genetically-modified adipose-derived stromal vascular fraction (ADSVF). In …

Propranolol and mesenchymal stromal cells combine to treat traumatic brain injury

DJ Kota, KS Prabhakara… - Stem Cells …, 2016 - academic.oup.com
More than 6.5 million patients are burdened by the physical, cognitive, and psychosocial
deficits associated with traumatic brain injury (TBI) in the US Despite extensive efforts to …

Ischemic brain stroke and mesenchymal stem cells: An overview of molecular mechanisms and therapeutic potential

Y Jingli, W Jing, Y Saeed - Stem Cells International, 2022 - Wiley Online Library
Ischemic brain injury is associated with a high rate of mortality and disability with no effective
therapeutic strategy. Recently, a growing number of studies are focusing on mesenchymal …

[HTML][HTML] Mechanisms and repair strategies for white matter degeneration in CNS injury and diseases

N Shahsavani, H Kataria… - Biochimica et Biophysica …, 2021 - Elsevier
White matter degeneration is an important pathophysiological event of the central nervous
system that is collectively characterized by demyelination, oligodendrocyte loss, axonal …

Adipose stromal vascular fraction-mediated improvements at late-stage disease in a murine model of multiple sclerosis

AC Bowles, AL Strong, RM Wise, RC Thomas… - Stem Cells, 2017 - academic.oup.com
Multiple sclerosis (MS) is a common neurodegenerative disease and remains an unmet
clinical challenge. In MS, an autoimmune response leads to immune cell infiltration …