[HTML][HTML] Novel agents for the pharmacological treatment of alcohol use disorder
Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …
[HTML][HTML] Animal models of compulsion alcohol drinking: why we love quinine-resistant intake and what we learned from it
T De Oliveira Sergio, RM Frasier, FW Hopf - Frontiers in Psychiatry, 2023 - frontiersin.org
Alcohol Use Disorder (AUD) ranks among the most prevalent mental disorders, extracting~
$250 billion/year in the US alone and producing myriad medical and social harms. Also, the …
$250 billion/year in the US alone and producing myriad medical and social harms. Also, the …
Noradrenergic circuits and signaling in substance use disorders
AM Downs, ZA McElligott - Neuropharmacology, 2022 - Elsevier
The central noradrenergic system innervates almost all regions of the brain and, as such, is
well positioned to modulate many neural circuits implicated in behaviors and physiology …
well positioned to modulate many neural circuits implicated in behaviors and physiology …
Noradrenergic targets for the treatment of alcohol use disorder
The role of norepinephrine (NE) in the development of alcohol use disorder (AUD) has been
studied over the past several decades. However, the NE system has been largely ignored …
studied over the past several decades. However, the NE system has been largely ignored …
New approved and emerging pharmacological approaches to alcohol use disorder: a review of clinical studies
Abstract introduction: The number of medications approved for AUD is small and they
generally have limited efficacy. We need new pharmacotherapies for the management of …
generally have limited efficacy. We need new pharmacotherapies for the management of …
Alterations in resting-state functional connectivity in substance use disorders and treatment implications
Substance use disorders (SUD) are diseases of the brain, characterized by aberrant
functioning in the neural circuitry of the brain. Resting state functional connectivity (rsFC) can …
functioning in the neural circuitry of the brain. Resting state functional connectivity (rsFC) can …
A randomized, placebo-controlled, clinical trial of prazosin for the treatment of alcohol use disorder
Objectives: The noradrenergic system plays an important role in the pathophysiology of
alcohol use disorder (AUD). Medications in this class may reduce drinking. Our aims were to …
alcohol use disorder (AUD). Medications in this class may reduce drinking. Our aims were to …
Treating posttraumatic stress disorder and alcohol use disorder comorbidity: Current pharmacological therapies and the future of MDMA-integrated psychotherapy
BJ Gully, E Eaton, C Capone… - Journal of …, 2023 - journals.sagepub.com
Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) frequently co-occur in
patients who have experienced trauma. This comorbidity leads to a vicious cycle where …
patients who have experienced trauma. This comorbidity leads to a vicious cycle where …
Alcohol addiction-the safety of available approved treatment options
M Antonelli, A Ferrulli, L Sestito… - Expert opinion on …, 2018 - Taylor & Francis
ABSTRACT Introduction: Alcohol Use Disorders (AUD) is a leading cause of mortality and
morbidity worldwide. At present disulfiram, naltrexone and acamprosate are approved for …
morbidity worldwide. At present disulfiram, naltrexone and acamprosate are approved for …
Effects of prazosin on provoked alcohol craving and autonomic and neuroendocrine response to stress in alcohol use disorder
V Milivojevic, GA Angarita, G Hermes… - Alcoholism: Clinical …, 2020 - Wiley Online Library
Background Chronic alcohol use results in changes to stress biology and autonomic arousal
contributing to acute alcohol withdrawal symptoms, neuroendocrine tolerance of the …
contributing to acute alcohol withdrawal symptoms, neuroendocrine tolerance of the …