Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid
tumors, and these insights have illuminated early detection, risk stratification, prevention …

Mobilizing antitumour immunity through vaccination potentially constitutes a powerful
anticancer strategy but has not yet provided robust clinical benefits in large patient …

Simple Summary Colorectal cancer (CRC) is the third most common cancer worldwide.
Metastasis to secondary organs, such as the liver and lungs, is a key driver of CRC-related …

Polyphenolic compounds, widely present in fruits, vegetables, and cereals, have potential
benefits for human health and are protective agents against the development of …

We examined the role of macrophages in inflammation associated with colorectal cancer
(CRC). Given the emerging evidence on immune-microbiota interactions in CRC, we also …

AIM To examine the effect of Fusobacterium nucleatum (F. nucleatum) on the
microenvironment of colonic neoplasms and the expression of inflammatory mediators and …

Colorectal cancer occurrence and progression involve multiple aspects of host immune
deficiencies. In these events, immune cells vary their phenotypes and functions over time …

Crosstalk of a tumor with its microenvironment is a critical factor contributing to cancer
development. This study investigates the soluble factors released by tumor-associated …

Colorectal cancer (CRC) is the third most diagnosed malignancy and the second leading
cause of cancer-related deaths worldwide. Locally advanced and metastatic disease exhibit …

The tumor microenvironment (TME) plays a key role in promoting the initiation and
progression of tumors, leading to chemoradiotherapy resistance and immunotherapy failure …