Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the
aged population. Current treatments for OA are largely palliative until the articular cartilage …

Summary Introduction Matrix metalloproteinases (MMPs) and 'aggrecanase'a disintegrin
and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play …

Cartilage damage is a key feature of degenerative joint disorders—primarily osteoarthritis
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …

Osteoarthritis genetics has been transformed in the past decade through the application of
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …

Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …

Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …

Osteoarthritis (OA) is an age‐related joint degenerative disease associated with pain, joint
deformity, and disability. The disease starts with cartilage damage but then progressively …

Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

A number of human diseases, such as arthritis and atherosclerosis, include characteristic
pathology in specific anatomical locations. Here we show transcriptomic differences in …

Mitochondria and mitochondrial DNA (mtDNA) variation are now recognized as important
factors in the development of osteoarthritis (OA). Mitochondria are the energy powerhouses …