New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis
H Li, D Wang, Y Yuan, J Min - Arthritis research & therapy, 2017 - Springer
Osteoarthritis (OA) is the most common joint disorder and affects approximately half of the
aged population. Current treatments for OA are largely palliative until the articular cartilage …
aged population. Current treatments for OA are largely palliative until the articular cartilage …
[HTML][HTML] Genetics of osteoarthritis
G Aubourg, SJ Rice, P Bruce-Wootton… - Osteoarthritis and …, 2022 - Elsevier
Osteoarthritis genetics has been transformed in the past decade through the application of
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …
Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings
T Pap, A Korb-Pap - Nature Reviews Rheumatology, 2015 - nature.com
Cartilage damage is a key feature of degenerative joint disorders—primarily osteoarthritis
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …
(OA)—and chronic inflammatory joint diseases, such as rheumatoid arthritis (RA) …
[HTML][HTML] ADAMTS and ADAM metalloproteinases in osteoarthritis–looking beyond the 'usual suspects'
CY Yang, A Chanalaris, L Troeberg - Osteoarthritis and cartilage, 2017 - Elsevier
Summary Introduction Matrix metalloproteinases (MMPs) and 'aggrecanase'a disintegrin
and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play …
and metalloproteinase with thrombospondin motifs (ADAMTSs) are well established to play …
Inflammation and epigenetic regulation in osteoarthritis
Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …
recognized that there is a major inflammatory component to this disease. In addition to …
Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?
AS Marchev, PA Dimitrova, AJ Burns… - Annals of the New …, 2017 - Wiley Online Library
Osteoarthritis (OA) is an age‐related joint degenerative disease associated with pain, joint
deformity, and disability. The disease starts with cartilage damage but then progressively …
deformity, and disability. The disease starts with cartilage damage but then progressively …
Interplay between genetics and epigenetics in osteoarthritis
Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …
in the past few years by the implementation of powerful genome-wide scans that have …
Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy
P Singh, KB Marcu, MB Goldring… - Annals of the New York …, 2019 - Wiley Online Library
Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …
Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
M Frank-Bertoncelj, M Trenkmann, K Klein… - Nature …, 2017 - nature.com
A number of human diseases, such as arthritis and atherosclerosis, include characteristic
pathology in specific anatomical locations. Here we show transcriptomic differences in …
pathology in specific anatomical locations. Here we show transcriptomic differences in …
Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes
Mitochondria and mitochondrial DNA (mtDNA) variation are now recognized as important
factors in the development of osteoarthritis (OA). Mitochondria are the energy powerhouses …
factors in the development of osteoarthritis (OA). Mitochondria are the energy powerhouses …