European Heart rhythm association (EHRA)/European association of cardiovascular prevention and rehabilitation (EACPR) position paper on how to prevent atrial …

EP Europace, 2017 - academic.oup.com
Atrial fibrillation (AF) is an important and highly prevalent arrhythmia, which is associated
with significantly increased morbidity and mortality, including a four-to five-fold increased …

New strategies for the treatment of atrial fibrillation

N Jost, T Christ, J Magyar - Pharmaceuticals, 2021 - mdpi.com
Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia in the clinical practice. It
significantly contributes to the morbidity and mortality of the elderly population. Over the past …

Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice

S Pabel, S Ahmad, P Tirilomis, T Stehle… - Basic Research in …, 2020 - Springer
Pharmacologic approaches for the treatment of atrial arrhythmias are limited due to side
effects and low efficacy. Thus, the identification of new antiarrhythmic targets is of clinical …

A Mechanistic Clinical Trial Using (R)- Versus (S)-Propafenone to Test RyR2 (Ryanodine Receptor) Inhibition for the Prevention of Atrial Fibrillation Induction

MB Shoemaker, ZT Yoneda, DM Crawford… - Circulation …, 2022 - Am Heart Assoc
Background: Experimental data suggest ryanodine receptor-mediated intracellular calcium
leak is a mechanism for atrial fibrillation (AF), but evidence in humans is still needed …

[HTML][HTML] Simulation of ectopic pacemakers in the heart: multiple ectopic beats generated by reentry inside fibrotic regions

BG de Barros, RW dos Santos, M Lobosco… - BioMed research …, 2015 - ncbi.nlm.nih.gov
The inclusion of nonconducting media, mimicking cardiac fibrosis, in two models of cardiac
tissue produces the formation of ectopic beats. The fraction of nonconducting media in …

Opportunities and challenges of current electrophysiology research: a plea to establish 'translational electrophysiology'curricula

DH Lau, PGA Volders, P Kohl, FW Prinzen… - EP …, 2015 - academic.oup.com
Cardiac electrophysiology has evolved into an important subspecialty in cardiovascular
medicine. This is in part due to the significant advances made in our understanding and …

Ambulatory cardiac arrhythmias in relation to mild hypokalaemia and prognosis in community dwelling middle-aged and elderly subjects

N Mattsson, G Sadjadieh, P Kumarathurai… - Europace, 2016 - academic.oup.com
Aims Severe hypokalaemia can aggravate arrhythmia tendency and prognosis, but less is
known about risk of mild hypokalaemia, which is a frequent finding. We examined the …

Atrial remodeling in permanent atrial fibrillation: mechanisms and pharmacological implications

DM Muntean, Z Kohajda, T Fazekas… - Journal of Clinical and …, 2013 - real.mtak.hu
Atrial fibrillation (AF), the most prevalent rhythm disorder in clinical practice, is currently
significantly contributing to morbidity and mortality of the ageing population. In the past …

Mild hypokalemia and supraventricular ectopy increases the risk of stroke in community-dwelling subjects

N Mattsson, P Kumarathurai, BS Larsen, OW Nielsen… - Stroke, 2017 - Am Heart Assoc
Background and Purpose—Stroke is independently associated with the common conditions
of hypokalemia and supraventricular ectopy, and we hypothesize that the combination of …

New antiarrhythmic targets in atrial fibrillation

N Voigt, J Heijman, D Dobrev - Future Cardiology, 2015 - Taylor & Francis
Atrial fibrillation (AF) is the most common cardiac arrhythmia in developed countries. AF is
associated with increased mortality and morbidity due to thromboembolism, stroke and …