Long noncoding RNAs as biomarkers in cancer

L Bolha, M Ravnik-Glavač, D Glavač - Disease markers, 2017 - Wiley Online Library
Long noncoding RNAs (lncRNAs) are a relatively well‐characterized class of noncoding
RNA (ncRNA) molecules, involved in the regulation of various cell processes, including …

Long non-coding RNAs and cancer: a new frontier of translational research?

R Spizzo, MI Almeida, A Colombatti, GA Calin - Oncogene, 2012 - nature.com
Tiling array and novel sequencing technologies have made available the transcription
profile of the entire human genome. However, the extent of transcription and the function of …

lncRNAdb: a reference database for long noncoding RNAs

PP Amaral, MB Clark, DK Gascoigne… - Nucleic acids …, 2011 - academic.oup.com
Large numbers of long RNAs with little or no protein-coding potential [long noncoding RNAs
(lncRNAs)] are being identified in eukaryotes. In parallel, increasing data describing the …

[HTML][HTML] Long non-coding RNA in cancer

N Hauptman, D Glavač - International journal of molecular sciences, 2013 - mdpi.com
Long non-coding RNAs (lncRNAs) are pervasively transcribed in the genome and are
emerging as new players in tumorigenesis due to their various functions in transcriptional …

Targeting non-coding RNAs with the CRISPR/Cas9 system in human cell lines

TT Ho, N Zhou, J Huang, P Koirala, M Xu… - Nucleic acids …, 2015 - academic.oup.com
The CRISPR/Cas has been recently shown to be a powerful genome-editing tool in a variety
of organisms. However, these studies are mainly focused on protein-coding genes. The …

[HTML][HTML] The genetic signatures of noncoding RNAs

JS Mattick - PLoS genetics, 2009 - journals.plos.org
The majority of the genome in animals and plants is transcribed in a developmentally
regulated manner to produce large numbers of non–protein-coding RNAs (ncRNAs), whose …

Long noncoding RNAs: emerging stars in gene regulation, epigenetics and human disease

A Bhan, SS Mandal - ChemMedChem, 2014 - Wiley Online Library
Noncoding RNAs (ncRNAs) are classes of transcripts that are encoded by the genome and
transcribed but never get translated into proteins. Though not translated into proteins …

Long non-coding RNAs as regulators of the endocrine system

M Knoll, HF Lodish, L Sun - Nature Reviews Endocrinology, 2015 - nature.com
Long non-coding RNAs (lncRNAs) are a large and diverse group of RNAs that are often
lineage-specific and that regulate multiple biological functions. Many are nuclear and are …

Common variants on 9q22. 33 and 14q13. 3 predispose to thyroid cancer in European populations

J Gudmundsson, P Sulem, DF Gudbjartsson… - Nature …, 2009 - nature.com
In order to search for sequence variants conferring risk of thyroid cancer we conducted a
genome-wide association study in 192 and 37,196 Icelandic cases and controls …

[HTML][HTML] Long non-coding RNAs and complex human diseases

J Li, Z Xuan, C Liu - International journal of molecular sciences, 2013 - mdpi.com
Long non-coding RNAs (lncRNAs) are a heterogeneous class of RNAs that are generally
defined as non-protein-coding transcripts longer than 200 nucleotides. Recently, an …