Osimertinib is an irreversible, third-generation epidermal growth factor receptor (EGFR)
tyrosine kinase inhibitor that is highly selective for EGFR-activating mutations as well as the …

At present, the idea of genome modification has revolutionized the modern therapeutic
research era. Genome modification studies have traveled a long way from gene …

The clustered regularly interspaced short palindromic repeats system has demonstrated
considerable advantages over other nuclease-based genome editing tools due to its high …

The development of genetic engineering in the 1970s marked a new frontier in genome-
editing technology. Gene-editing technologies have provided a plethora of benefits to the life …

Simple Summary Clustered regularly interspaced short palindromic repeats (CRISPR)-
CRISPR associated protein (Cas) 9 is a novel technology utilized to modify target genes …

Clustered regularly interspaced short palindromic repeats‐associated protein
(CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust …

Cancer is characterized by multiple genetic and epigenetic alterations that drive malignant
cell proliferation and confer chemoresistance. The ability to correct or ablate such mutations …

One of the fundamental discoveries in the field of biology is the ability to modulate the
genome and to monitor the functional outputs derived from genomic alterations. In order to …

Clinical evidence indicates that drug resistance is a great obstacle in breast cancer therapy.
It renders the disease uncontrollable and causes high mortality. Multiple mechanisms …

Proliferating cells regularly experience replication stress caused by spontaneous DNA
damage that results from endogenous reactive oxygen species (ROS), DNA sequences that …