Estimated glomerular filtration rate in chronic kidney disease: a critical review of estimate-based predictions of individual outcomes in kidney disease
Chronic kidney disease (CKD) is generally regarded as a final common pathway of several
renal diseases, often leading to end-stage kidney disease (ESKD) and a need for renal …
renal diseases, often leading to end-stage kidney disease (ESKD) and a need for renal …
[HTML][HTML] Heterogeneity of absorbed dose distribution in kidney tissues and dose–response modelling of nephrotoxicity in radiopharmaceutical therapy with beta …
CS Vargas, M Andersson, C Bouvier-Capely… - … für Medizinische Physik, 2023 - Elsevier
Absorbed dose heterogeneity in kidney tissues is an important issue in radiopharmaceutical
therapy. The effect of absorbed dose heterogeneity in nephrotoxicity is, however, not fully …
therapy. The effect of absorbed dose heterogeneity in nephrotoxicity is, however, not fully …
A novel multiplex biomarker panel for profiling human acute and chronic kidney disease
Acute and chronic kidney disease continues to confer significant morbidity and mortality in
the clinical setting. Despite high prevalence of these conditions, few validated biomarkers …
the clinical setting. Despite high prevalence of these conditions, few validated biomarkers …
Cell interactome in sarcopenia during aging
L González‐Blanco, M Bermúdez… - Journal of Cachexia …, 2022 - Wiley Online Library
Background The diversity between the muscle cellular interactome of dependent and
independent elderly people is based on the interrelationships established between different …
independent elderly people is based on the interrelationships established between different …
SIRT1/Nrf2/NF-κB signaling mediates anti-inflammatory and anti-apoptotic activities of oleanolic acid in a mouse model of acute hepatorenal damage
Background and objectives: Oleanolic acid (OA) is a penta-cyclic triterpene with diverse
bioactivities such as anticarcinogenic, antiviral, antimicrobial, hepatoprotective, anti …
bioactivities such as anticarcinogenic, antiviral, antimicrobial, hepatoprotective, anti …
Risk factor mining and prediction of urine protein progression in chronic kidney disease: a machine learning-based study
Y Lu, Y Ning, Y Li, B Zhu, J Zhang, Y Yang… - BMC Medical Informatics …, 2023 - Springer
Background Chronic kidney disease (CKD) is a global public health concern. Therefore, to
provide timely intervention for non-hospitalized high-risk patients and rationally allocate …
provide timely intervention for non-hospitalized high-risk patients and rationally allocate …
Differential renal proteomics analysis in a novel rat model of iodinated contrast-induced acute kidney injury
YH Deng, XF Wang, X Wu, P Yan, Q Liu, T Wu… - Renal …, 2023 - Taylor & Francis
Contrast-induced acute kidney injury (CI-AKI), which occurs after the use of iodinated
contrast media, has become the third leading cause of hospital-acquired acute kidney injury …
contrast media, has become the third leading cause of hospital-acquired acute kidney injury …
Endogenous markers of kidney function and renal drug clearance processes of filtration, secretion, and reabsorption
LE Thompson, MS Joy - Current opinion in toxicology, 2022 - Elsevier
The kidneys are responsible for maintaining physiologic homeostasis. The kidneys clear a
variety of drugs and other substances through passive (filtration) and active processes that …
variety of drugs and other substances through passive (filtration) and active processes that …
Maximum Tolerated Dose (MTD) Studies in Drug Toxicology Assessments
YE Koshman, BR Winters, J Ryans, S Authier… - Drug discovery and …, 2023 - Springer
In order to transition a new chemical entity (NCE) from the discovery arena into nonclinical
development and potentially the clinic, a comprehensive nonclinical safety profile must be …
development and potentially the clinic, a comprehensive nonclinical safety profile must be …
Nephroprotective Activity of Papaloquelite (Porophyllum ruderale) in Thioacetamide-Induced Injury Model
MJ Vázquez-Atanacio, M Bautista… - Plants, 2022 - mdpi.com
Acute kidney injury and impaired kidney function is associated with reduced survival and
increased morbidity. Porophyllum ruderale is an edible plant endemic to Mexico used in …
increased morbidity. Porophyllum ruderale is an edible plant endemic to Mexico used in …